Volume 17, Issue 2 (8-2026)
JAP 2026, 17(2): 44-57 |
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Ethics code: IR.IUMS.FMD.REC.1402.121
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Khatibi A, Nouri N, Rokhtabnak F, Djalali Motlagh S, asgari G. Comparison of Three Different Doses of Intrathecal Isobaric Ropivacaine for Spinal Anesthesia in Elective Cesarean Section: A Randomized Clinical Trial. JAP 2026; 17 (2) :44-57
URL: http://jap.iums.ac.ir/article-1-5828-en.html
URL: http://jap.iums.ac.ir/article-1-5828-en.html
1- , nouri.na@iums.ac.ir
Abstract: (26 Views)
Background and Objectives: Spinal anesthesia ranks among the most widely used and safest approaches for cesarean delivery. Compared to bupivacaine, ropivacaine poses a reduced risk of cardiac and neurological toxicity while still achieving adequate sensory and motor blockade, making it a strong candidate for spinal anesthesia in this setting. This study sought to evaluate three doses of isobaric ropivacaine (10, 12.5, and 15 mg) in terms of their effects on blood pressure stability and nerve block quality in patients undergoing cesarean section.
Methods: This double-blind randomized trial was carried out on 104 pregnant women scheduled for elective cesarean section at Firoozgar Hospital. Participants were randomly assigned to receive intrathecal isobaric ropivacaine at one of the three doses. Patient demographics, block onset and duration, hemodynamic measurements, adverse event rates, block failure frequency, and patient satisfaction were all documented and analyzed.
Results: The three groups showed no meaningful differences in age, height, or other baseline characteristics. Similarly, no statistically significant distinctions emerged between groups in cardiovascular responses, block onset timing, or the duration of sensory and motor blockade. Rates of side effects were also broadly equivalent across groups. Notably, however, block failure occurred less frequently in the 15 mg group (13.5%) than in the 10 mg (23%) and 12.5 mg (17.5%) groups.
Conclusion: Choosing the right dose requires weighing anesthetic effectiveness against the potential for side effects. Therefore, 15 mg of isobaric ropivacaine may represent a preferable dose for spinal anesthesia in elective cesarean deliveries.
Methods: This double-blind randomized trial was carried out on 104 pregnant women scheduled for elective cesarean section at Firoozgar Hospital. Participants were randomly assigned to receive intrathecal isobaric ropivacaine at one of the three doses. Patient demographics, block onset and duration, hemodynamic measurements, adverse event rates, block failure frequency, and patient satisfaction were all documented and analyzed.
Results: The three groups showed no meaningful differences in age, height, or other baseline characteristics. Similarly, no statistically significant distinctions emerged between groups in cardiovascular responses, block onset timing, or the duration of sensory and motor blockade. Rates of side effects were also broadly equivalent across groups. Notably, however, block failure occurred less frequently in the 15 mg group (13.5%) than in the 10 mg (23%) and 12.5 mg (17.5%) groups.
Conclusion: Choosing the right dose requires weighing anesthetic effectiveness against the potential for side effects. Therefore, 15 mg of isobaric ropivacaine may represent a preferable dose for spinal anesthesia in elective cesarean deliveries.
Keywords: Ropivacaine, Spinal Anesthesia, Cesarean Section, Hemodynamics, Block Quality, Optimal Dose
Type of Study: Applicable |
Subject:
Gynecologic anesthesia
Received: 2026.06.6 | Accepted: 2026.06.29 | Published: 2026.08.1
Received: 2026.06.6 | Accepted: 2026.06.29 | Published: 2026.08.1
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