Volume 15, Issue 1 (5-2024)
JAP 2024, 15(1): 13-22 |
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Ethics code: IR.IAU.SHAHROOD.REC.1397.043
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Avazzadeh A, Babaei H, Kalhor A, Jannati Toupkanloo K, Zamen Ghadirli A, Yahyaei B. Investigating the effects of short-term and long-term doses of injectable ketamine on the histopathology of the cerebral cortex in infants of exposed maternal rats. JAP 2024; 15 (1) :13-22
URL: http://jap.iums.ac.ir/article-1-5694-en.html
URL: http://jap.iums.ac.ir/article-1-5694-en.html
Alireza Avazzadeh1 
, Hessamedin Babaei1 , Aria Kalhor2 , Kimia Jannati Toupkanloo1 , Afagh Zamen Ghadirli1 , Behrooz Yahyaei 3
, Hessamedin Babaei1 , Aria Kalhor2 , Kimia Jannati Toupkanloo1 , Afagh Zamen Ghadirli1 , Behrooz Yahyaei 3
1- Student Research Committee, Shahrood Branch, Islamic Azad University, Shahrood, Iran
2- Department of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
3- Department of Medical Sciences, Biological Nanoparticles in Medicine Research center, Shahrood Branch, Islamic Azad University, Shahrood, Iran ,behroozyahyaei@yahoo.com
2- Department of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
3- Department of Medical Sciences, Biological Nanoparticles in Medicine Research center, Shahrood Branch, Islamic Azad University, Shahrood, Iran ,
Abstract: (107 Views)
Background:
The high use of ketamine in different treatment regimens, as well as its abuse for non-medical purposes, especially in recent years, has led to concern about its side effects. In the following study, an attempt has been made to investigate the effect of ketamine on the cerebral cortex tissue of fetuses obtained from exposed maternal rats.
Method:
The study was conducted on 15 female rats (3 groups of 5 including the control group, the long-term anesthetized group with ketamine, the short-term and repeated anesthetized group with ketamine). Then, the histopathological changes of the cerebral cortex of newborns resulting from the fertility of mice receiving ketamine were evaluated. In the implementation of this plan, the ethics of working with laboratory animals have been observed.
Result:
The findings of our study showed that no changes were observed in the brain tissue and different layers in the samples of the control group, and the brain tissue was reported completely clear and normal. In the short-term and long-term dose groups of ketamine, there was no change compared to the control group, and only the number of microglia cells was lower compared to the control group.
Conclusion:
Exposure to ketamine during embryogenesis can prevent cell proliferation in the neuronal area of the cerebral cortex of rat embryos. In the present study, a decrease in microglia cells was observed in both groups injected with ketamine, but significant tissue and structural changes were observed in the two recipient groups. Ketamine was not seen compared to the control group.
The high use of ketamine in different treatment regimens, as well as its abuse for non-medical purposes, especially in recent years, has led to concern about its side effects. In the following study, an attempt has been made to investigate the effect of ketamine on the cerebral cortex tissue of fetuses obtained from exposed maternal rats.
Method:
The study was conducted on 15 female rats (3 groups of 5 including the control group, the long-term anesthetized group with ketamine, the short-term and repeated anesthetized group with ketamine). Then, the histopathological changes of the cerebral cortex of newborns resulting from the fertility of mice receiving ketamine were evaluated. In the implementation of this plan, the ethics of working with laboratory animals have been observed.
Result:
The findings of our study showed that no changes were observed in the brain tissue and different layers in the samples of the control group, and the brain tissue was reported completely clear and normal. In the short-term and long-term dose groups of ketamine, there was no change compared to the control group, and only the number of microglia cells was lower compared to the control group.
Conclusion:
Exposure to ketamine during embryogenesis can prevent cell proliferation in the neuronal area of the cerebral cortex of rat embryos. In the present study, a decrease in microglia cells was observed in both groups injected with ketamine, but significant tissue and structural changes were observed in the two recipient groups. Ketamine was not seen compared to the control group.
Keywords: Ketamine, Histopathology, Cerebral Cortex, Short term dose, Long term dose, Maternal Rats, Infant Rats
Type of Study: Original |
Subject:
Gynecologic anesthesia
Received: 2022.11.9 | Accepted: 2023.12.31 | Published: 2024.05.30
Received: 2022.11.9 | Accepted: 2023.12.31 | Published: 2024.05.30
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