Journal of Anesthesiology and Pain

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 Aims and Background: Based    on    existing    scientific    information,    Thymus    vulgaris    and    Matricaria    chamomilla    are    two    kinds    of    herbs    with    some    anti-inflammatory    effects.    There    are    some    serious    side    effects    such    as    psychological dependence or blood dyscrasia subsequent to using synthetic drugs in order to treat unpleasant feeling    due    to    Visceral    pain.    In    order    to    lessen    the    side    effects,    administration    of    herbal    medicines    could    be    helpful.    The purpose of this study is evaluating the palliative effects of hydroalcholic extracts of Thymus vulgarisand Matricaria chamomilla  and their Synergistic effects on visceral pain. Materials and Methods: This experimental study was performed on 40 N-MRI male mice (36±4g) who were randomly    divided    into    five    groups:    the    Negative    Control    group    treated    with    normal    saline,    Positive    Control    group    treated    with    Flunixin    meglumine(2    mg/kg)    and    the    groups    of    Thymus    vulgaris    therapy(300mg/kg),    Matricaria chamomilla therapy (300mg/kg) and the last one  that received both Thymus and Matricaria (total 300mg/kg).These groups received drugs and hydroalcholic extracts with intraperitonial injection. The Mice were injected with acetic acid 0.6% (10ml/kg) to make visceral pain; 15 minutes after each intraperitonial administration, the palliative effects were recorded by counting the number of writhing in 30 minutes. The data    was    analyzed    by    SPSS    statistical    software    and    One-Way    ANOVA    (Tukey)    test.    The    significant    value    was    shown with (p <0.001). Findings: Co-administration    of    Thymus    vulgaris    (150    mg/kg)    and    Matricaria    chamomilla    (150    mg/kg)    showed    a    significant    reduction    of    pain    compared    to    negative    control    group(p<0.001).    But    administration    of    Thymus    vulgaris    (300    mg/kg)    and    Matricaria    chamomilla(300    mg/kg)    seperately,    do    not    induce    any    significant    response    compared to negative control group(p>0.001). Conclusion: Co-administration    of    Thymus    vulgaris    and    Matricaria    chamomilla    can    be    more    effective    than    their    single    administration;    however    further    clinical    studies    are    necessary    to    find        a    suitable    place    for    them    among other visceral analgesics.

Keywords: Thymus plant, Matricaria, Visceral Pain, Analgesics

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