Volume 7, Issue 3 (12-2016)                   JAP 2016, 7(3): 30-37 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Keramati K, Asghari BaghKheirati A, abdollahi M, yaghmaee M, abdollahi M. The effect of hydroalcoholic extract of Ferula gummosa on visceral pain in mice: Experimental study. JAP 2016; 7 (3) :30-37
URL: http://jap.iums.ac.ir/article-1-5286-en.html
1- semnan university
2- semnan university , Amir.asghari598@gmail.com
3- veterinary
Abstract:   (6675 Views)


Background: Visceral pain is  unpleasant felling that Using synthetic drugs for treatment has some side effects, such as psychological dependence and blood dyscrasia and for decreasing these side effects, administration of herbal medicine can be appropriate approach. Based on existing information in traditional medicine and some recent scientific surveys, Ferula gummosa plant is one type of herbs that has different therapeutic effects of which it is possible to point to antibacterial, antifungal, antioxidant and anti-inflammatory effects.The aim of this study is evaluation of palliative effect of Ferula gummosa on visceral pain.

Methods: This experimental study was done on 40 NMRI male mice. (36±4g). Mice were divided randomly into control group, positive group (flunixine), treatment 1 , treatment 2 ,treatment 3. Respectively Control group and positive group received normal salin and flunixine (2mg/kg) and also treatment groups respectively received 25, 50 ,100 mg/kg of Ferula gummosa intraperitoneally. 15minute after each injection , for visceral pain induction , mices were injected by acetic acid 0.6% (10mg/kg) and during  30 minutes, the analgesic effect was recorded by counting the number of Writing. Datas were analyzed by SPSS statistical software , One-Way ANOVA and Tukey test with the significant level of P< 0.05.

Results: The extracts of Ferula gummosa with 25, 50, 100 mg/kg doses in compared with   negative control doesn’t induced a significant reduction in pain response (P<0.05).

Conclusion: This study confirms that Ferula gummosa had no palliative properties on visceral pain. But further studies are necessary to find out an Analgesic effect of its components.

Full-Text [PDF 296 kb]   (2807 Downloads)    
Type of Study: Original | Subject: Acute pain managment
Received: 2016.04.19 | Accepted: 2016.09.14 | Published: 2016.12.16

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Anesthesiology and Pain

Designed & Developed by : Yektaweb