Effect of single dose premedication with pregabaline on pain afterminor surgery

Mohammad Molla‐Soltani3,Keivan Niknam3, Farnad Imani1, Mahmoud Nezafati2, Majid Heidarian2; ,; ,; ,; ,

Volume 3, Issue 2 (8 2012) JAP 2012, 3(2): 180-0 | Back to browse issues page

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Mohammad Molla‐Soltani3,Keivan Niknam3 F I M N M H. Effect of single dose premedication with pregabaline on pain afterminor surgery. JAP 2012; 3 (2) :180-0
URL: http://jap.iums.ac.ir/article-1-38-en.html

Effect of single dose premedication with pregabaline on pain afterminor surgery

Farnad Imani1, Mahmoud Nezafati2, Majid Heidarian2 Mohammad Molla‐Soltani3,Keivan Niknam3

Abstract: (5412 Views)

Aim and Background:

Optimal postoperative pain management is necessary after minor general

surgery. Although pregabalin had been showed efficacy against neuropathic pain, very limited

evidence support its postoperative analgesic efficacy. The aim of this study was to evaluate the

analgesic efficacy of premedication with single oral dose of pregabalin for minor general surgery.

Methods and Materials:

Sixty patients candidate for minor general surgery under general
anesthesia were randomly allocated into the two groups In intervention group Pregabalin 150mg

, and in control group placebo was administered one hour before surgery. Anesthesia method was

similar in both groups. If pain score (Visual Analogue Scale, VAS) was more than three,

pethidine 25mg intravenous was administrated. VAS, opioid consumption, and side effects were

recorded for 24 hours after surgery.

Findings:

Demographic data was not significantly different between two groups. VAS and
opioid consumption during the 24 hours postoperative period in pregabalin group was

significantly less than the placebo group without any more side effects (

p
<0.01).

Conclusions:

Preoperative administration of single oral dose of pregabalin 150mg reduced post