Journal of Anesthesiology and Pain

Background: Propofol is one of the most common drugs used in anesthesia induction and the pain during its intravenous injection is the most important and another side effect of it. Therefore a lot of methods and drugs are examined to reduce or eliminate this side effect. In this study the effects of Alfentanil, Magnesium sulfate and Ketamin drugs on reducing of pain during intravenous injection of propofol are investigated. 
Methods: This study was performed on 220 patients who were under orthopedic surgery in Poursina hospital in 2010. The intensity of propofol intravenous injection pain is measured after using premedication by VAS, result is analyzed by SPSS v16 software under Chi square and PostHoc exams.
Results: According to data and variance analysis statistic exam ANOVA it is definded that after propofol injection there is a meaningful difference in quantity of VAS among studied groups (Chi square = 49.78 and df = 3 and P<0.0001). The VAS score in Magnesium sulfate group has a meaningful difference in comparison of other groups according to PostHoc exams and there is no meaningful difference among other groups (P>0.05).
Conclusion: Despite reduction the propofol intravenous injection pain in three studies drugs in this thesis, there is no preference among them.