Volume 15, Issue 4 (2-2025)
JAP 2025, 15(4): 44-56 |
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Ethics code: IR.SUMS.MED.REC.1396.35
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eghbal M, pirahmadi A, abbasi A, khosravi M B, valipour A, farhadi M. The effect of aminophylline on renal function after liver transplant surgery. JAP 2025; 15 (4) :44-56
URL: http://jap.iums.ac.ir/article-1-5780-en.html
URL: http://jap.iums.ac.ir/article-1-5780-en.html
Mohammadhossein Eghbal1 
, Afra Pirahmadi1 , Alireza Abbasi2 , Mohammad bagher Khosravi3 , Amin Valipour4 , Mohammad Farhadi 5
, Afra Pirahmadi1 , Alireza Abbasi2 , Mohammad bagher Khosravi3 , Amin Valipour4 , Mohammad Farhadi 5
1- Anesthesiology resident, Department of Anesthesiology and Critical Care, Anesthesia and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- MD, Clinical research development center, Amir oncology hospital, Shiraz University of Medical Sciences, Shiraz, Iran
3- Associate Professor, Department of Anesthesiology and Critical Care, Anesthesia and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- . Anesthesiology resident, , Department of Anesthesiology and Critical Care, Anesthesia and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5- MD, Clinical research development center, Amir oncology hospital, Shiraz University of Medical Sciences, Shiraz, Iran ,fsunroo@gmail.com
2- MD, Clinical research development center, Amir oncology hospital, Shiraz University of Medical Sciences, Shiraz, Iran
3- Associate Professor, Department of Anesthesiology and Critical Care, Anesthesia and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- . Anesthesiology resident, , Department of Anesthesiology and Critical Care, Anesthesia and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5- MD, Clinical research development center, Amir oncology hospital, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract: (97 Views)
Abstract
Background:
The risk of kidney injuries following liver transplantation surgery is high. Aminophylline, a non-specific adenosine receptor antagonist, has been suggested as a preventive measure against post-operative kidney injury.
Methods:
This double-blind, randomized clinical trial involved 100 patients divided into two groups: Group A (intervention group, 50 patients) received aminophylline, while Group B (control group, 50 patients) received standard care. Variables were measured pre-and post-operatively for up to 5 days, and the results were analyzed.
RESULT:
The use of aminophylline was associated with a 2% reduction in the incidence of kidney failure, a 12% reduction in severe kidney function loss, and a 12% reduction in moderate kidney function loss compared to the control group. However, no statistically significant difference between the intervention and control groups regarding KDGIO (Kidney Disease: Improving Global Outcomes) levels was observed. The mean serum AST levels on the fourth and fifth postoperative days, hospital stay duration, and IVC clamp time were lower in the intervention group (p < 0.05).
Discussion and Conclusion:
The results of this study suggest that, despite the positive effects of aminophylline on GFR (glomerular filtration rate), it does not significantly reduce kidney failure based on the updated KDGIO criteria.
Background:
The risk of kidney injuries following liver transplantation surgery is high. Aminophylline, a non-specific adenosine receptor antagonist, has been suggested as a preventive measure against post-operative kidney injury.
Methods:
This double-blind, randomized clinical trial involved 100 patients divided into two groups: Group A (intervention group, 50 patients) received aminophylline, while Group B (control group, 50 patients) received standard care. Variables were measured pre-and post-operatively for up to 5 days, and the results were analyzed.
RESULT:
The use of aminophylline was associated with a 2% reduction in the incidence of kidney failure, a 12% reduction in severe kidney function loss, and a 12% reduction in moderate kidney function loss compared to the control group. However, no statistically significant difference between the intervention and control groups regarding KDGIO (Kidney Disease: Improving Global Outcomes) levels was observed. The mean serum AST levels on the fourth and fifth postoperative days, hospital stay duration, and IVC clamp time were lower in the intervention group (p < 0.05).
Discussion and Conclusion:
The results of this study suggest that, despite the positive effects of aminophylline on GFR (glomerular filtration rate), it does not significantly reduce kidney failure based on the updated KDGIO criteria.
Type of Study: Original |
Subject:
Postanesthesia Care
Received: 2025.01.9 | Accepted: 2025.01.10 | Published: 2025.02.28
Received: 2025.01.9 | Accepted: 2025.01.10 | Published: 2025.02.28
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