Journal of Anesthesiology and Pain

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 Aims and background: Postoperative nausea and vomiting is a distressing situation with a prevalence of 10 - 30%. As dexamethasone and metoclopramide are inexpensive drugs and cause little complications, and ondasetron in turn is a good and high quality drug for relieving patients ftom nausea and vomiting, we compared the effect of dexamethasone and metoclopramide versus dexamethasone and ondasetron on nausea - vomiting and shivering in patients undergoing laparoscopic cholecystectomy, in the study. Materials and methods: The present study is a randomized, double - blind clinical trial. After obtaining consent from pations, study was performed on 88 patients allocated with sampling and blocking method. The first group received the combination of dexamethasone and ondasetron, and the second group received the combination of  dexamethasone and metoclopramide. The anesthetist injecting drugs,was unaware of the type of injectable medicine. The anesthetic method and the drugs used for anesthesia were the same in both groups. After the operation, the questionair asked questions about nausea - vomiting and shivering for up to 24 hours (at intervals of 1 - 6 -12 and 24 hours), and all the answers were recorded for each participant. Finally all findings were analyzed statistically using spss version 20. Findings: In this study 88 patients were divided into 2 groups. the first group received the combination of dexamethasone and ondasetron, and the second group received combination of dexamethasone and metoclopramide. the mean average age in the D+O group was 41.07 years and in the D+M group was 42.16 years. The result of this study showed that there was insignificant decrease in nausea and vomiting after laparoscopic cholecystectomy;also none of the patients in the study groups showed any shivering. Conclusion: The result of this study showed that the combination of ondasetron and dexamethasone could not significantly reduce the incidance of post operative nausea and vomiting compared to combination of dexamethasone and metoclopramide. No patients in the study groups had shivering.

Keywords: dexamethasone, ondasetron, metoclopramide, nausea, vomiting, shivering, laparoscopic.

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