Journal of Anesthesiology and Pain

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 Aims and background: Intraoperative blood loss during craniotomy for brain tumor excision needs blood transfer in most of the cases. Tranexamic acid is an anti-fibrin lytic drug. The aim of this study was to evaluate the effect of Tranexamic acid on intraoperative blood loss in patients undergoing craniotomy for brain tumor excision. Materials and Methods: Fifty patients suffering from brain tumor underwent craniotomy. Thirty minutes before incision, patients were randomly allocated into two groups of intervention (Tranexamic acid) or control group (normal saline). Fifteen mg/kg Tranexamic acid in combination with 500 cc normal saline in a 30 minutes period was injected in the form of bolus in the intervention group. In control group, patients received normal saline in same amounts. Intraoperative blood loss was estimated by observing Suction bottles, weighting the used medical gauzes and the remained blood on the surgery field during the surgery. This was done by counting small cotton and converting the surgery field to used medical gauzes. Blood loss was measured every one hour. Findings: The mean blood loss during surgery in the intervention group was 858±314 and 1050±398 in the control group. Although this amount was less in intervention group, the trend was not significant (P= 0.076). Also the mean amount of estimated blood loss in intervention group was 798± 365 and 906±378 in the control group (P=0.31). conclusion: Tranexamic acid administration may decrease the blood loss but this study could not observe any significant trend. The number of blood pack cells and estimated blood loss were not significantly different in two groups of intervention and control.

Keywords: Bleeding, Teranexamic Acid, craniotomy, Brain tumor

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