Volume 3, Issue 2 (8 2012)                   JAP 2012, 3(2): 152-0 | Back to browse issues page

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Sina Asgarian‐omran3 M M A E. The effect of oral clonidine premedication on blood loss and thequality of the surgical field during endoscopic sinus surgery: aplacebo-controlled clinical trial. JAP 2012; 3 (2) :152-0
URL: http://jap.iums.ac.ir/article-1-34-en.html
Abstract:   (8620 Views)















Aim and Background:


Bleeding during functional endoscopic sinus surgery(FESS)remains a

challenge for both surgeons and anesthesiologists despite several modalities available for

improving the surgical field. This study was conducted to evaluate the effect of oral clonidine

premedication on blood loss and the quality of the surgical field in FESS.

Methods and Materials:


In a placebo-controlled clinical trial, a total of 84 American Society of

Anesthesiologists (ASA) physical status I–II patients undergoing endoscopic sinus surgery for

chronic sinusitis were randomly allocated to receive either oral clonidine 0.2 mg or identicallooking

placebo tablets 90 min before arrival at the operating room.



Blood loss in the clonidine group was 214 ± 67 ml on average and that in the placebo

group was 276 ± 78 ml (mean ± SD, p"0.01). The median (range) bleeding score in the clonidine

group was significantly lower than that in the placebo group (2 (1–3) vs. 2.5 (2–4), p<0.0001).

Accordingly, the surgeon was more satisfied with the surgical field in the clonidine group than

with that in the placebo group (median score, 4 (3–5) vs. 3 (1–5), p<0.001).



Premedication with oral clonidine 0.2 mg can effectively reduce bleeding during FESS.




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Type of Study: Original | Subject: General
Accepted: 2018.12.10 | Published: 2018.12.10

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