Showing 11 results for Propofol
Hossain Madineh, Mohammad-Reza Abedin-Zadeh, Fatemeh Jafari,
Volume 1, Issue 3 (10-2010)
Abstract
Background and aims
Secondary brain damage due to head trauma is one of the causes of death especially in young victims. Prolonged disability and death happen in most severe head trauma cases. Use of hypnotic drugs such as benzodiazeapine, barbiturates and propofol plus opioids cause sedation for respiratory support by mechanical ventilation. This study investigated the efficacy of thiopental in compare with propofol in mortality rate and prognosis of patients with severe head trauma.
Material and methods
130 patients suffering from head injury with GCS =8 randomly divided to two groups. They were treated with infusion of thiopental or propofol for 48 hours. Then their clinical signs improvement, mortality rate and remained of clinical symptoms evaluated for 3 months.
Results
Patients under propofol treatment had better prognosis than the other group.
Conclusions
Propofol better protects brain tissue from hydrogen peroxide and reduces metabolic rate at early hours of injuries with better brain perfusion. These reduce secondary brain injury and secondary disability.
Valiollah Hassani, Zahra Taghipour-Anvari, Nazanin Mirabi, Atousa Deljo,
Volume 1, Issue 4 (1-2011)
Abstract
Background and aims: To compare intubating conditions and cardiovascular changes follow
induction of anesthesia and tracheal intubation in patients receiving either lidocaine-remifentanilpropofol
or lidocaine-remifentanil-sevoflurane prior to induction.
Methods and materials: In a randomized, double-blind study 75 healthy children patients
were assigned to one of two groups: lidocaine 1.5 mg·kg-1, remifentanil 2 μg·kg-1 and propofol
2 mg·kg-1 (Group P) or lidocaine 1.5 mg·kg-1, remifentanil 2 μg·kg-1 and sevoflurane (Group
S). Then laryngoscopy and tracheal intubation were attempted at BIS 40-50. Intubating conditions
were assessed as excellent, good or poor on the basis of ease of ventilation, position of the vocal
cords, and patient's response to intubation and slow inflation of the tracheal cuff. The mean
arterial pressure (MAP) and heart rate (HR) were measured before anesthetic agent
administration, immediately after tracheal intubation, and five minutes after intubation.
Results: Excellent intubating conditions were obtained in 76% of Group P patients and 84% of
Group S patients and were not significantly different between the two groups (p<0.356).
Cardiovascular changes following induction of anesthesia and tracheal intubation were not
significantly different between the two groups.
Conclusion: Lidocaine-remifentanil-sevoflurane is similar and safe like lidocaine-remifentanilpropofol
for tracheal intubation without muscle relaxants in children.
Bijan Yazdi, Mohammad Khalili, Houshang Talebi, Ali-Reza Fotovat, Arezou Nikaeen,
Volume 2, Issue 2 (7-2011)
Abstract
Introduction: According to the importance of hemodynamic stability during anesthesia, usage of drugs and technics which change the hemodynamic in a minimum rate has become one of the most important purposes.Widely spread usage of propofol for sedation in cataract surgery made us to evaluate the effect of ketamine,which in itself has sympathetic effects, in usage accompaning with propofol.
Materials and Methods: In a double blinded clinical trial 110 patients whom were candidate for cataract surgery were divided in two groups accidentally. After dripping topical analgesic drop and intravenous fentanyl injection 1mcg/kg : In one of the groups 0.25 mg/kg ketamine and in the other one 2cc normal saline were injected. Propofol infusion was started up to reaching to Ramsy score 3. Blood pressure, pulse rate and arterial O2 saturation were measured before and after injection of drug or placebo and also every 2 minutes for 10 minutes and the every 5 minutes up to end of surgery and transportation to recovery. Recovery time and propofol prescribed dosage were also measured. The results were analyzed with SPSS software.
Results: The average of systolic blood pressure and diastolic blood pressure was higher in 2 and 6 minutes and diastolic blood pressure was higher in minute 4 in ketamine group after injection. After injection and 2 minute later the average of pulse rate was higher in ketamine group. Also the usage of propofol in ketamine group was less and the recovery time was longer.
Conclusion: Although the recovery time in ketamine - propofol usage is longer but it provides a better stability in patients hemodynamic and also reduces the propofol dosage.
Ali Mohammadzadeh, Mohammad Haghighi, Sirous Amir-Alavi, Bahram Naderi-Nabi, Ali Mohammadzadeh, Majid Nekoofard, Mohsen Abad,
Volume 2, Issue 3 (10-2011)
Abstract
Background: Propofol is one of the most common drugs used in anesthesia induction and the pain during its intravenous injection is the most important and another side effect of it. Therefore a lot of methods and drugs are examined to reduce or eliminate this side effect. In this study the effects of Alfentanil, Magnesium sulfate and Ketamin drugs on reducing of pain during intravenous injection of propofol are investigated.
Methods: This study was performed on 220 patients who were under orthopedic surgery in Poursina hospital in 2010. The intensity of propofol intravenous injection pain is measured after using premedication by VAS, result is analyzed by SPSS v16 software under Chi square and PostHoc exams.
Results: According to data and variance analysis statistic exam ANOVA it is definded that after propofol injection there is a meaningful difference in quantity of VAS among studied groups (Chi square = 49.78 and df = 3 and P<0.0001). The VAS score in Magnesium sulfate group has a meaningful difference in comparison of other groups according to PostHoc exams and there is no meaningful difference among other groups (P>0.05).
Conclusion: Despite reduction the propofol intravenous injection pain in three studies drugs in this thesis, there is no preference among them.
Mahmoudreza Alebouyeh, Saeidreza Entezari, Hamidreza Feiz, Atefe Alaee,
Volume 2, Issue 4 (3-2012)
Abstract
Background:Use of drugs with short apnea duration and less hemodynamic changes for intubation of trachea in intensive care units is necessary. This study compares the effects of propofol and sodium thiopental on hemodynamic changes and apnea duration after tracheal intubation in patients admitted to intensive care units.
Methods:In this double blind clinical trial, 25 ICU-admitted patients were evaluated. They were intubated two times with 72 hours interval, once received 1.5mg/kg sodium thiopental, and the other time 0.75 mg/kg propofol, while the drug used for intubation in the first time was randomly selected. Hemodynamic variables include systolic and diastolic BP, heart rate, MAP, RPP, MAP/HR and apnea duration in two times, during pre intubation, intubation and after intubation were measured.Data were analysed with statistical tests of independent's t and ANOVA repeated test.
Results: In comparison with pre-intubation, hemodynamic variables such as systolic and diastolic BP, MAP and MAP/HR were decresed during tracheal intubation in both groups, but range of changes in propofol group is less than those of thiopental group and the difference is statistically significant (P<0.0001).
Conclusion:In comparison with thiopental, Propofol has fewer changes in hemodynamics in patients who needed tracheal intubation, and also has short er apnea period. Accordingly use of propofol over thiopental is recommended for tracheal intubation in ICU patients.
Vahid Alizadeh , Behzad Kazemihaki, Javad Eftekhari , Parasto Tizro,
Volume 5, Issue 1 (4-2014)
Abstract
Aims and Background: Propofol is one of the newest and the most common drugs in anesthesia and intensive care unit which is used to produce sedative effects. One of its complications is the pain produced at the time of injection. The aim of this study is to compare the pain of Propofol injection with two techniques: Propofol mixed with lidocaine and Propofol injection after lidocaine.
Materials and methods: This study is a randomized double-blind clinical trial, in which 172 patients undergoing elective surgery with ASA class one and two were enrolled. Three groups of patients had injections as follows: In the first group 40 mg Propofol mixed with 2% lidocaine, in the second one purified one percent propofol, and in the third group Propofol following injection of 40 mg lidocaine 2%, were injected. Venous catheter 20 gauge was used in all cases for injection, and pain intensity was measured by VRS (Verbal Rating Scale) criteria. The data were analyzed by SPSS V.18 .
Findings: Pain intensity in the second group (Propofol injection after lidocaine injection) was less than the first group (mixed injection) and there was a statistically significant difference between the two groups (P<0.05). The hemodynamic changes were similar in both groups, and there was no significant difference (P>0. 05).
Conclusions: Pre-treatment by injecting 40 mg of lidocaine2% to reduce pain due to Propofol injection is more effective than mixed method of injecting 40 mg of Propofol with lidocaine 2% .
, ,
Volume 7, Issue 3 (12-2016)
Abstract
Introduction: Anesthesia can change the balance between proinflammatory and anti-inflammatory cytokine factors during surgery. As a result of interference in the balance of these factors, increase the risk of cardiac and pulmonary disorders, blood glucose levels with insulin resistance, impaired function and damage to the patient's anesthesia. The aim of this study was to investigate the pattern of IL-10 and TNF-α with two type of anesthesia in surgery of Roux-en-Y laparoscopic gastric.
Material: 64 patients undergoing laparoscopic gastric bypass referring to Hazrat Rasoul Hospital as a random and using block randomization and parallel divided into two groups. After pre-oxygenation, anesthesia induction and patient intubation, as the maintenance of anesthesia during the operation, in first group isoflurane 1.2% is used and in second group propofol 100 μ / kg/ min is used intravenously. Then in groups, interluekin 10 and TNFα by ELISA method is measured.
Result: According to the results, the amount of IL-10 in both types of anesthesia increased, but increasing the amount of IL-10 in the propofol group showed unprecedented high. The amount of TNF-alpha in the isoflurane group; a little high, but decreased in the propofol group. The results of the statistical confidence level p <0.05 was significant.
Conclusion: Intraoperative stress factors responsible for the increase inflammation factor such as TNF-α. The use of drugs, such as propofol, may be helpful for reduce inflammation during surgery.
Dr Mehrdad Malekshoar, Dr Hashem Jarineshin, Dr Saeed Kashani, Dr Fereydoon Fekrat, Dr Raziyeh Raz, Dr Majid Vatankhah,
Volume 8, Issue 2 (7-2017)
Abstract
Aim and Background: Electroconvulsive therapy (ECT) is considered as the most effective treatment method for major depression and psychiatric disorders. Significant hemodynamic changes occur in patients treated with ECT and the duration of seizure after ECT is considered as an important factor in the success of this treatment method. This study aimed to compare the effect of etomidate and propofol on seizure duration and hemodynamic parameters in ECT. Methods and Materials: This study is a double blind clinical trial on 27 patients (54 patient sessions), aged 12-60 years with ASA class I-II. In the first patient session induction of anesthesia for ECT was applied by either propofol (2 mg/kg) or etomidate (0.2 mg/kg) and for the second patient session (with a time interval of 48 hours) the other drug was applied. Systolic blood pressure, diastolic blood pressure and heart rate were measured and recorded in four stages of ECT once before and then 1, 3 and 5 minutes after ECT. Seizure duration was measured in each session. Data analysis was applied by SPSS software and a P value <0.05 was considered significant. Findings: The mean age of participants in this study was 35.9 ± 10.4. The mean duration of seizure during propofol and etomidate anesthesia was 35.14 and 35.74 seconds, respectively (P = 0.240). Mean systolic and diastolic blood pressure and heart rate every time after seizure during propofol anaesthesia was less than etomidate (P =0.05). conclusions: There was no significant difference regarding seizure duration and hemodynamic changes subsequent to ECT, between propofol and etomidate anesthesia
Dr Javad Shahinfar, Mr Hossein Zeraati, Miss Maryam Ghorban Zadeh, Mr Shayan Vafaei, Miss Fatimeh Hashemi,
Volume 8, Issue 2 (7-2017)
Abstract
Aims and background: Post operative nausea and vomiting is one of the most common complications after surgery. The newest drug for induction and maintenance of anesthesia is propofol. Its consumption due to the rapid onset, short duration of action, Anti-nausea and vomiting property and comfortable feeling after surgery is on the rise. Materials and Methods: In this clinical trial, 90 patients undergoing general surgery were randomly divided into three groups. In the first group induction-dose was 1/5mg/kg propofol, in the second group, induction-dose was 2 mg/kg propofol and in the third group, 2/5mg/kg propofol was used. Based on self-reporting scale and frequency of vomiting, the evaluation condidering the severity and incidence of nausea and vomiting was done in three stages: Exactly after the surgery, and 2 and 6 hours afterwards. Data was analyzed by Spss software. Findings: The results showed that considering age, gender, duration of NPO time, and operation time, no significant difference was found among the three groups. Based on one-way analysis of variance there was no significant difference between groups in severity and incidence of nausea and vomiting. conclusion: Propofol has positive effect incontrolling nausea and vomiting after surgery in different doses. Therefore, administration of Propofol (with divided doses and without the need for pumps) is simple and cheap.
, Masood Mohseni, , ,
Volume 11, Issue 4 (12-2020)
Abstract
Introduction: Increased serum lactate is seen during surgery due to tissue hypoxia. There have been reports of propofol infusion syndrome due to long-term use of this drug, especially in intensive care patients. This study was conducted to evaluate the factors affecting serum lactate levels in patients under general anesthesia with propofol in spine surgery.
Methods: In a cross-sectional study, 70 patients undergoing elective spine surgery (laminectomy) in the operating room of Rasoul Akram Hospital in 1398 were included in the study. Propofol was used to maintain anesthesia. Mean arterial blood pressure, heart rate, pH, arterial bicarbonate, arterial dioxide pressure, arterial base excess and serum lactate were measured and recorded during surgery and at the end of surgery. Parameters determining serum lactate levels were examined in a logistic regression model.
Results: Logistic multivariate regression analysis showed that ASA, hemoglobin, blood transfusion and mean arterial blood pressure were significant predictors of high serum lactate in patients (P <0.05). The variables of hemoglobin, blood transfusion and arterial bicarbonate of patients are statistically significant in predicting high open arterial access in patients (P <0.05).
Conclusion: Hemoglobin, blood transfusion and mean arterial blood pressure predict the development of high serum lactate in patients under general anesthesia with propofol.
Behzad Nazemroaya, Seyed Taghi Hashemi, Moeen Rezaei,
Volume 13, Issue 3 (11-2022)
Abstract
Background: Propofol is commonly used in anesthesia practice because of its rapid recovery time, but pain upon injection is one of the unfavorable complications of this drug, which can cause both physical and mental discomfort for patients. Therefore, it is important to lower the pain on injection of Propofol in patients undergoing anesthesia. As a result, the current study was conducted in order to compare the effects of lidocaine, lidocaine, and the Valsalva maneuver, and the Valsalva maneuver on decreasing the pain of Propofol injection.
methods: This study is a clinical trial with 111 patients. The patients were allocated into 3 groups with one group receiving lidocaine, the second group receiving lidocaine and the Valsalva maneuver , and Valsalva maneuver. The pain resulting from injecting Propofol based upon the Visual Analog Scale (VAS) score was evaluated (with 1 being no pain and 10 the most severe imaginable pain). Data were compared and analysed using proper statistical tests using SPSS version 23.
Results: The mean pain score in the combination group of lidocaine and Valsalva maneuver was lower than the other two groups and was equal to 0.5 ± 0.33. In addition, the mean pain scores in the lidocaine group and the Valsalva maneuver group were 4.6 ± 1.41 and7.81±1/91, respectively. The mean pain intensity in the age groups and the sexes did not show a significant difference with each other.
Conclusion: The current study showed that the injection of Propofol in the three groups of the study was reduced in a similar fashion, however in the group which combined lidocaine, Valsalva, and the Valsalva maneuver, pain was lowest, but the overall score in the three groups was not statistically different.
