Showing 10 results for Lidocaine
Houshang Talebi, Bijan Yazdi, Shabanali Alizadeh, Esmaleel Moshiry, Afsaneh Nourozi,
Volume 1, Issue 3 (10-2010)
Abstract
Background and aims
The efficacy of adding midazolam to intrathecal bupivacaine has been widely documented. The aim of this study was to assess the effects of combination of intrathecal midazolam and lidocaine on postoperative pain.
Methods
In a randomized controlled trial that was performed in 2007 in a teaching hospital of Arak University of Medical Sciences, forty five male patients who were candidates for elective inguinal herniorrhaphy entered and randomly divided into three groups of Control (lidocaine 5% plus Normal saline), M0.5 (lidocaine 5% and midazolam 0.5mg) and M1 (lidocaine 5% and midazolam 1 mg) according to intrathecal solution injected for spinal anesthesia. Mean arterial blood pressure, heart rate, post-operative pain, narcotic requirements, and complications (nausea, vomiting, pruritis, headache, hypotension and bradycardia) were recorded.
Results
The severity of post-operative pain was lowest in M1 group in all postoperative measurements except at 2 hours after operation.There was significant difference in vomiting between three groups which had the highest frequency in M0.5 group. No severe hypotension was seen though, bradycardia occurred in one patient in M0.5 group which needed treatment.
Conclusions
Our findings suggest that administration of intrathecal midazolam (especially 1mg) together with lidocaine is effective in reducing post-operative pain in patients undergoing open inguinal herniorrhaphy and is not associated with adverse effect.
Seyyed-Hossein Moshtaghion, Amir-Mohammad Mohsenpour, Zahra Hashemianp, Hamid-Reza Faiz,
Volume 1, Issue 3 (10-2010)
Abstract
Background and aims
We have compared the effects of lidocaine, remifentanil and placebo on the hoemodynamic
responses to tracheal extubation.
Methods
This was a prospective, randomized clinical trial, double-blind study in 18 to 50 years old adults
with ASA I - II, undergoing an orthopedic surgery. Anesthesia was induced with fentanyl 2 μg/kg
IV and propofol 1.5 mg/kg and atracurium 0.6 mg/kg, and maintained with propofol 100
μg/kg/min and repeated doses of atracurium 0.2 mg/kg. Ten and 50 minutes before the end of
surgery, propofol and fentanyl were discontinued respectively. At the end of surgery a bolus
dose of Remifentanil 0.25 μg/kg or Lidocaine 1.5 mg/kg or 5 ml normal saline was given and
tracheal extubation was performed after standard criteria acheivement. Arterial pressure and
heart rate were recorded at the time of 1,5,10 intervals from the end of surgery.
Results
There were statistically significant differences between the lidocaine and remifentanil group
with respect to hemodynamic parameters (heart rate, diastolic blood pressure) at 5, 10 min
intervals from the end of surgery. Systolic blood pressure at three times was significantly
different in three groups.
Conclusions
Remifentanil is more effective than lidocaine on cardiovascular response control during
emergence from anesthesia and extubation.
Saeid-Reza Entezary, Farnad Imani, Mahmoud-Reza Alebouyeh, Amir-Aziz Seif,
Volume 1, Issue 3 (10-2010)
Abstract
Background and aims
Although calcium channel blockers such az verpamile are added to local anesthetics for regional anesthesia,rarely they may cause undesirable hemodynamic side effects This study compared the hemodynamic and blockade effects of verapamile and sufentanile during axillary brachial plexus blockade with lidocaine 1.5% .
Methods
Forty five patients were divided randomly into 3 groups. Patients in group 1 received 1.5% lidocaine patients group 2 received 105% lidocaine mixed with 5 mg verapamilepatients in group 3 received 1.5% lidocaine mixed with 5 mg verapa,ile and 5 μg sufentanile . Hemodynamic data were measured four times. The duration time of anesthesia and sensory block was recorded.
Results
The beginning time of anesthesia was similar in 3 groups, but analgesia duration was significantly longer in groups 3 and 2 than in group 1 (p<0.05) . There were no significant differences in Hemodynamic data between 3 groups.
Conclusions
Verapamile offers more stable hemodynamics and similar blockade, and thus may be beneficial for ASA I patients undergoing forearm and hand surgery.
Ali-Reza Mirkheshti, Mohammad-Reza Aryani, Ali Dabbagh, Morteza Jabbary-Moghaddam, Seyyed-Sajjad Razavi, Hedayatollah Elyasi, Arash Mohammadi-Tofigh,
Volume 2, Issue 3 (10-2011)
Abstract
Background: Intravenous regional anesthesia (IVRA) is an efficient method for short-term procedures of the upper extremities. Some defects are associated with IVRA including tourniquet-related pain and insufficient duration of the anesthesia. The main purpose of the current study was to compare the effects of adding paracetamol or magnesium sulfate to lidocaine in IVRA on pain, venous blood gasses (VBG) and sensory and motor block.
Methods: There were 90 patients contributed in the current study. Patients were divided into paracetamol (P), magnesium sulfate (Mg) and control (C) groups, randomly. Severity of the pain, time interval between the injection and onset of the sensory and motor block, duration of the sensory and motor block and the changes of VBG were measured.
Results: The onset of the sensory and motor block was reduced significantly in Mg group (p<0.05). There was a meaningful increase in the motor block duration in Mg group in relation to C group (p<0.05), but no statistically significant difference between Mg and P groups. Also, there was no meaningful difference between C and P groups in the means of onset of block and block duration. Neither MgSO4 nor paracetamol decreased the tourniquet-related pain. The changes of VBG were significantly lesser in the P group.
Conclusion: Adding MgSO4 to lidocaine improves the sensory and motor block in the IVRA. In other hand, paracetamol prevents ischemic changes to occur. None of these drugs are helpful to relief the tourniquet-related pain.
Alireza Mahoori, Ebrahim Hassani, Ghader Motarjemizadeh, Shahrzad Mojtahedi,
Volume 4, Issue 4 (1-2014)
Abstract
Aim and Background: The analgesic effect of perioperative low doses of intravenous lidocaine has been demonstrated in some studies. Sodium channel blockers are approved for IV administration in the treatment of neuropathic pain states. Our objective in this study was to determine the analgesic, antiemetic and sedative effect of perioperative lidocaine administration in strabismus surgery.
Methods and Materials: In a randomized and double blinded clinical trial, forty patients undergoing strabismus surgery were evaluated. Twenty patients received lidocaine (bolus injection of 1.5 mg/kg) at the end of operation, before tracheal extubation and 20 patients received saline as placebo. Postoperative pain scorr, pethidine requirement, nausea -vomiting and sedation were assessed in the recovery room. Findings: Patients who received lidocaine reported less pain and needed less pethidine during their recovery state. There were also fewer incidences of nausea and vomiting in the lidocaine group. Patients in the lidocaine group were more sedated than the ones in the control group.
Conclusions: Intravenous lidocaine has analgesic activity, besides its preventing effect on nausea and vomiting after strabismus surgery.
Seyyed Ali Emami, Masoud Ganji, Ebrahim Espahbodi,
Volume 4, Issue 4 (1-2014)
Abstract
Aim and background: Our goal to perform this study was to evaluate the effect of adding lidocaine to the irrigation solution during knee arthroscopy on decreasing patient's degree of pain.
Methods and materials: This was a randomized double blind study, in which 41 patients were enrolled in each group. In the control group, the irrigation solution in arthroscopy was just normal saline without any adjuvant. However in our cases, the solution contained 0.5 mg per ml lidocaine. The patients were compared according to their degree of pain and opioid request in the ward up to 6 hours thereafter. Findings: The visual analogue pain scale showed that the score of pain was significantly decreased in the case group in comparison with the control one. Moreover, the patients in the case group had significantly less request for opioids after arthroscopy.
Conclusions: Adding lidocaine to the irrigation solution in knee arthroscopy could be an effective method to lower the degree of pain in patients.
Vahid Alizadeh , Behzad Kazemihaki, Javad Eftekhari , Parasto Tizro,
Volume 5, Issue 1 (4-2014)
Abstract
Aims and Background: Propofol is one of the newest and the most common drugs in anesthesia and intensive care unit which is used to produce sedative effects. One of its complications is the pain produced at the time of injection. The aim of this study is to compare the pain of Propofol injection with two techniques: Propofol mixed with lidocaine and Propofol injection after lidocaine.
Materials and methods: This study is a randomized double-blind clinical trial, in which 172 patients undergoing elective surgery with ASA class one and two were enrolled. Three groups of patients had injections as follows: In the first group 40 mg Propofol mixed with 2% lidocaine, in the second one purified one percent propofol, and in the third group Propofol following injection of 40 mg lidocaine 2%, were injected. Venous catheter 20 gauge was used in all cases for injection, and pain intensity was measured by VRS (Verbal Rating Scale) criteria. The data were analyzed by SPSS V.18 .
Findings: Pain intensity in the second group (Propofol injection after lidocaine injection) was less than the first group (mixed injection) and there was a statistically significant difference between the two groups (P<0.05). The hemodynamic changes were similar in both groups, and there was no significant difference (P>0. 05).
Conclusions: Pre-treatment by injecting 40 mg of lidocaine2% to reduce pain due to Propofol injection is more effective than mixed method of injecting 40 mg of Propofol with lidocaine 2% .
Karim Hemmati , Tayebeh Sayadizadeh , Ali Delpisheh, Zahra Ahmadian Mazhyn,
Volume 5, Issue 2 (7-2014)
Abstract
Aims and Background : One of the most common surgeries in women is cesarean section. Hence, it is important to choose an anesthetic technique which is safe, appropriate and affordable for mom and baby. Spinal anesthesia is one of such techniques for which drugs with the least possible damage and most efficacy should be chosen. Among the additives to local anesthetics, "epinephrine" is an appropriate choice. Epinephrine is commonly used together with local anesthetic to induce tense block and it seems that adding epinephrine to lidocaine would improve sensory block during spinal anesthesia.
Materials and Methods: This study is a randomized double blind clinical trial. 60 female patients were referred to the operating room of Mostafa Khomeini hospital in Ilam. The patients were divided into two groups receiving lidocaine alone and lidocaine plus epinephrine. The first group received 60mg lidocaine 5% and the second group received 60mg of lidocaine 5% and 0.2 mg epinephrine. Afterward, variables such as systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, and arterial oxygen saturation by pulse oximetry, level of sensory, motor and sympathetic block, and Apgar score of neonate at 1 and 5 minutes plus possible complications of anesthetic drugs were recorded. Finally the findings were analyzed by multivariate statistical methods.
Findings: We measured different kinds of variables and the results are as follows. Average Pulse Rate after 5 minutes in the first and second groups were, 101/8 ± 31/51 and 107/4 ± 25/04, respectively. This was statistically significant among the groups. A higher level block was more common (with exception in one dermatome) in group one (lidocaine alone) which was confirmed to be statistically different (P <0/04). Regarding blood pressure decrease, no significant difference was shown between the two groups.
Conclusion: According to this study, we can conclude that there has been a longer continuation of the sensory, motor and sympathetic block in the group receiving lidocaine plus epinephrine in comparison with the group who received lidocaine alone. In this study the use of additional anesthetic agents was also dramatically reduced. This in fact expresses the efficacy of epinephrine in prolonging local anesthetic effect.
Bahram Naderi Nabi, Abbas Sedighinejad2, Mohammad Haghighi , Hamed Hasanzadh Moghadam, Samaneh Ghazanfar Tehran, Nasim Ashoori Saheli ,
Volume 5, Issue 3 (10-2014)
Abstract
Aims and background:
Due to the nature of the orthopaedic surgery, affecting bone and joint, it is
associated with a high rate of postoperative pain. Using intravenous,
intramuscular, intrathecal and epidural opioids are methods for postoperative
pain control for which the side effects are numerous. However, Intrathecal
administration of magnesium with blocking NMDA receptors reduces postoperative
pain without increasing side effects .The aim of this study was to investigate
the effect of adding magnesium sulfate to Intrathecal lidocaine- epinephrine
mixture on duration of postoperative analgesia in lower limb orthopaedic
surgeries.
Materials and Methods:
This double blind study was performed on patients who were candidate for lower
extremity orthopaedic surgeries. For this purpose, 156 patients were randomly
divided into two groups. One group received magnesium sulfate with lidocaine –
epinephrine mixture and other group received the same drugs with distilled
water as placebo. The duration of postoperative pain was determined according
to patients' request for analgesics. Patients' pain degree was evaluated
according to visual analogue score (VAS), and Pethedine consumption was also
calculated. Data were analyzed by SPSS software.
Findings: Mean age of our
patients in magnesium and control groups were 34.5 ±7.5 and 31.9±8.1 years old,
respectively. The Mean (±SD) of postoperative analgesia duration in the
magnesium group was 143.7±29.7min and it was 100.9±18.1 min in the control
group, which shows a significant difference between two groups (p <0. 000).
Patients’ pain score according to VAS in magnesium group was 3.9±o.36 and it
was 5.65±0.35 in the control one. This was also significantly different between
the two groups (p=0.000). Also mean Pethedine consumption was 15±6.24 mg and
33±6.27mg in the magnesium and control groups, which was again statistically
significant (p=0.000).
Conclusions: Magnesium
sulfate combined with lidocaine produces a reduction in postoperative pain in
comparison with lidocaine alone.
Behzad Nazemroaya, Seyed Taghi Hashemi, Moeen Rezaei,
Volume 13, Issue 3 (11-2022)
Abstract
Background: Propofol is commonly used in anesthesia practice because of its rapid recovery time, but pain upon injection is one of the unfavorable complications of this drug, which can cause both physical and mental discomfort for patients. Therefore, it is important to lower the pain on injection of Propofol in patients undergoing anesthesia. As a result, the current study was conducted in order to compare the effects of lidocaine, lidocaine, and the Valsalva maneuver, and the Valsalva maneuver on decreasing the pain of Propofol injection.
methods: This study is a clinical trial with 111 patients. The patients were allocated into 3 groups with one group receiving lidocaine, the second group receiving lidocaine and the Valsalva maneuver , and Valsalva maneuver. The pain resulting from injecting Propofol based upon the Visual Analog Scale (VAS) score was evaluated (with 1 being no pain and 10 the most severe imaginable pain). Data were compared and analysed using proper statistical tests using SPSS version 23.
Results: The mean pain score in the combination group of lidocaine and Valsalva maneuver was lower than the other two groups and was equal to 0.5 ± 0.33. In addition, the mean pain scores in the lidocaine group and the Valsalva maneuver group were 4.6 ± 1.41 and7.81±1/91, respectively. The mean pain intensity in the age groups and the sexes did not show a significant difference with each other.
Conclusion: The current study showed that the injection of Propofol in the three groups of the study was reduced in a similar fashion, however in the group which combined lidocaine, Valsalva, and the Valsalva maneuver, pain was lowest, but the overall score in the three groups was not statistically different.
