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Ghodrat Akhavan Akbari1, Mehdi Samadzadeh2, Bita Shahbazzadegan3 Behrouz Shokouhi4,firouz Amani5, Amin Allaf Asghari6, , , , , ,
Volume 3, Issue 2 (8 2012)
Abstract

 

 

 

 

 

 

 

 

 

Aim and Background:

 

Long exposure to inhalant anesthetic gases especially halothane, among

the known hepatotoxic agents, is a serious health risk for the staff of operating room. Current

study was performed to compare the level of hepatic enzymes between Operating&aposs room staff

and other therapeutic wards’ personnel out of the operating room.

Methods and Materials:

 

A total of 100 personnel from educational hospitals were included and

their demographic and occupational information were recorded. Hepatic function tests and

bilirubin were analyzed. In cases with values more than normal, in order to rule out hepatitis B

and C, Hbs-Ag, Hbs-Ab and HCV-Ab were tested.

Findings:

 

Demographic information and employment span were comparable in two groups. The

average of ALT, AST were significantly higher among operating room&aposs staff in comparison with

the other group (P<0.05) and there was no significant difference between the average of GGT and

ALP between two groups (P>0.05). ALT, AST and GGT indicated significantly increase with the

age of personnel (more than 40 years) and increase in employment period (more than 15 years).

Conclusions:

 

The operating room&aposs staff in educational hospitals of Ardabil may be exposed to

 

 

 


Mohammadjavad Asghariebrahimabad, Faezeh Salayani, Ali Mashhadi, Reza Attarzadeh Hosseini, Hossein Mashhadinejad, Sima Eftekharzadeh, Reihaneh Ahmadzadeh,
Volume 6, Issue 1 (4-2015)
Abstract

Abstract

 

Aim and Background: Chronic pain is a health issue that affects on millions of people in around the world. Research has indicated that psychological factors such as anxiety and aggression are common consequences of living with chronic pain. The aim of the present study was to investigate the effectiveness of cognitive therapy for females with chronic pain.

Methods: This was a quasi-experiment study with pretest-posttest design with a control group. In this study, 40 females with chronic musculoskeletal pain were recruited and 18 females with high score in anxiety and aggression were selected. They were divided randomly in two groups including, cognitive group therapy and the control group (9 persons per each group). Participants completed the DASS-21, Aggression questionnaire, Multidimensional pain inventory.  The cognitive group therapy was adopted for experimental group over eight weeks and participants again completed the post treatment assessments. Analysis of Covariance was used for analyzing the data.

Results: The Results showed that anxiety (p<0/05) and aggression (p<0/05) in experimental group has significantly difference in comparison with the control group.

Conclusion: According to the research findings, cognitive therapy can reduce anxiety and aggression in females with chronic pain.

 


Keyvan Keramati, Ashkan Jebelli Javan, Mostafa Abdollahi, Amir Asghari Bagh Kheirati,
Volume 7, Issue 1 (4-2016)
Abstract

Aims and Background: Visceral pain is  unpleasant felling that there are same serious side effects associated with using synthetic drugs for its treatment, such as psychological dependence, gastric ulcers and blood dyscrasia and for decreasing these side effects, administration of herbal medicine can be appropriate approach. The aim of this study was to evaluate the palliative effect of Commiphora  mukul hydroalcholic extract on visceral pain.

Methods: This experimental study was done on 40 NMRI male mice. (36±4g). Mice were divided randomly into negative control group, positive control group (Ketoprofen), treatment 1 , treatment 2 ,treatment 3. Respectively Control group and positive group received normal salin and Ketoprofen (25mg/kg) and also treatment groups respectively received 100, 200 ,300 mg/kg of Commiphora mukul intraperitoneally. 15minute after each injection , for visceral pain induction, mices were injected by acetic acid 0.6% (10mg/kg) and during  30 minutes, the analgesic effect was recorded by counting the number of Writing. Datas were analyzed by SPSS statistical software , One-Way ANOVA and Tukey test with the significant level of P< 0.05.

Results: Hydroalcoholic extracts of Commiphora mukul  at 100, 200 and 300 mg/kg induced a significant reduction in pain response when compared to negative control group (p<0.05) ,also there was not any significant difference between treatments groups and positive control group(p>0.05).

Conclusion: This study confirmed the palliative properties of Commiphora mukul on visceral pain but further clinical studies are necessary to find out a suitable place for it among the other visceral analgesics.


Keyvan Keramati, Amir Asghari Baghkheirati, Mostafa Abdollahi, Marziye Yaghmaee, Morteza Abdollahi,
Volume 7, Issue 3 (12-2016)
Abstract

Abstract

Background: Visceral pain is  unpleasant felling that Using synthetic drugs for treatment has some side effects, such as psychological dependence and blood dyscrasia and for decreasing these side effects, administration of herbal medicine can be appropriate approach. Based on existing information in traditional medicine and some recent scientific surveys, Ferula gummosa plant is one type of herbs that has different therapeutic effects of which it is possible to point to antibacterial, antifungal, antioxidant and anti-inflammatory effects.The aim of this study is evaluation of palliative effect of Ferula gummosa on visceral pain.

Methods: This experimental study was done on 40 NMRI male mice. (36±4g). Mice were divided randomly into control group, positive group (flunixine), treatment 1 , treatment 2 ,treatment 3. Respectively Control group and positive group received normal salin and flunixine (2mg/kg) and also treatment groups respectively received 25, 50 ,100 mg/kg of Ferula gummosa intraperitoneally. 15minute after each injection , for visceral pain induction , mices were injected by acetic acid 0.6% (10mg/kg) and during  30 minutes, the analgesic effect was recorded by counting the number of Writing. Datas were analyzed by SPSS statistical software , One-Way ANOVA and Tukey test with the significant level of P< 0.05.

Results: The extracts of Ferula gummosa with 25, 50, 100 mg/kg doses in compared with   negative control doesn’t induced a significant reduction in pain response (P<0.05).

Conclusion: This study confirms that Ferula gummosa had no palliative properties on visceral pain. But further studies are necessary to find out an Analgesic effect of its components.


Faezeh Salayani, Dr Mohammad Javad Asghari Ebrahimabad, Dr Ali Mashhadi, Dr Reza Attarzadeh Hoseini, Dr Reihaneh Ahmadzadeh Ghavidel, Dr Hosein Mashhadinejad,
Volume 8, Issue 1 (5-2017)
Abstract

 Aim and background:Chronic pain is an important public health problem that seriously affects people’s everyday lives. Aggression has been widely observed in patients with chronic pains and several studies have suggested that aggression is highly associated with chronic pain intensity. The aim of the current study was to test the effectiveness of cognitive self-management program in reducing aggression and multidimensional pain symptoms in women with chronic pain. Methods and Materials: The design of this study was quasi-experimental with pretest-posttest design, including control group which 30 women eligible chronic musculoskeletal pain more than three months (with the mean age 36.60 ± 2.26  yr) were selected by available and  Judgmental sampling. Participants had physiological and psychological trauma. Then they were randomly assigned to treatment (n=15) and control group (n=15). Participants completed the Aggression Questionnaire (AQ) and Multidimensional Pain Inventory (MPI) and in two phases of pre-test and post-test. Treatment consisted of eight sessions of cognitive self-management program over eight weeks. Analysis of Covariance was used for analyzing the data. Findings:    The    Results    showed    significant    reductions    of    aggression    (p<0/001)    and    multidimensional    pain    symptoms    (p<0/05)    compared    to    the    control    group. conclusions: These    results    suggest    that    cognitive    self-management    program    is    efficient    and    useful    in    reduction    multidimensional pain symptoms and aggression in women with chronic pain.


Amir Asghari Bagh Kheirati, Mostafa Abdollahi, Keyvan Keramati, Fahimeh Rezaei,
Volume 8, Issue 2 (7-2017)
Abstract

 Aims and Background: Based    on    existing    scientific    information,    Thymus    vulgaris    and    Matricaria    chamomilla    are    two    kinds    of    herbs    with    some    anti-inflammatory    effects.    There    are    some    serious    side    effects    such    as    psychological dependence or blood dyscrasia subsequent to using synthetic drugs in order to treat unpleasant feeling    due    to    Visceral    pain.    In    order    to    lessen    the    side    effects,    administration    of    herbal    medicines    could    be    helpful.    The purpose of this study is evaluating the palliative effects of hydroalcholic extracts of Thymus vulgarisand Matricaria chamomilla  and their Synergistic effects on visceral pain. Materials and Methods: This experimental study was performed on 40 N-MRI male mice (36±4g) who were randomly    divided    into    five    groups:    the    Negative    Control    group    treated    with    normal    saline,    Positive    Control    group    treated    with    Flunixin    meglumine(2    mg/kg)    and    the    groups    of    Thymus    vulgaris    therapy(300mg/kg),    Matricaria chamomilla therapy (300mg/kg) and the last one  that received both Thymus and Matricaria (total 300mg/kg).These groups received drugs and hydroalcholic extracts with intraperitonial injection. The Mice were injected with acetic acid 0.6% (10ml/kg) to make visceral pain; 15 minutes after each intraperitonial administration, the palliative effects were recorded by counting the number of writhing in 30 minutes. The data    was    analyzed    by    SPSS    statistical    software    and    One-Way    ANOVA    (Tukey)    test.    The    significant    value    was    shown with (p <0.001). Findings: Co-administration    of    Thymus    vulgaris    (150    mg/kg)    and    Matricaria    chamomilla    (150    mg/kg)    showed    a    significant    reduction    of    pain    compared    to    negative    control    group(p<0.001).    But    administration    of    Thymus    vulgaris    (300    mg/kg)    and    Matricaria    chamomilla(300    mg/kg)    seperately,    do    not    induce    any    significant    response    compared to negative control group(p>0.001). Conclusion: Co-administration    of    Thymus    vulgaris    and    Matricaria    chamomilla    can    be    more    effective    than    their    single    administration;    however    further    clinical    studies    are    necessary    to    find        a    suitable    place    for    them    among other visceral analgesics.
Keyvan Keramati, Mostafa Abdollahi, Amir Asghari Bagh Kheirati, Morteza Abdollahi, Danial Shaenannia Galesh Kalami,
Volume 8, Issue 2 (7-2017)
Abstract

 Aim and Background: Based on existing scientific information Thymus vulgaris is a medical herb which has anti- inflammatory effects. Visceral pain is an unpleasant feeling, however its treatment with NSAIDs results in serious side effects such as gastric ulcer, blood dyscrasia and Renal failure. In order to decrease these side effects and the dosage of drugs, co-administration of synergistic herbal medicine with these drugs can be a solution. The aim of this study was to evaluate the palliative interactive effect of hydroalcholic extract of Thymus vulgaris and Flunixinmeglumine on visceral pain. Methods and Materials: This experimental study was performed on 40 N-MRI male mice (36±4g).Animals were randomly divided into five groups: Negative Control group treated with normal saline, Positive Control group treated with Flunixin (2 mg/kg) and treatment groups receiving Flunixin (1mg/kg), Thymus vulgaris(100mg/kg) and both Thymus(100mg/kg) plus Flunixin(1mg/kg). All these groups received drugs and hydroalcholic extracts via intraperitonial injection. The Mices were injected with acetic acid 0.6% (10ml/kg) for visceral pain induction, and 15 minutes after each intraperitoneal administration, palliative effects were recorded by counting the number of Writhing during 30 minutes. The data was analyzed by SPSS using One-Way ANOVA (Tukey) test. The significant value was shown with p <0.001. Findings: The positive control group and treatment groups showed a significant reduction in pain response when compared to negative control group (p>0.001). Both Postive control and Thymus-Flunixin groups had a significant reduction in pain response in comparison with both Flunixin and Thymus groups (p<0.001) but they showed no significant difference relative to each other (p>0.001). conclusions: Co-administration of Thymus vulgaris and Flunixin results in synergistic analgesic effect.
Mojtaba Aghili, Sajad Abasi, Arezou Asghari,
Volume 14, Issue 2 (8-2023)
Abstract

Background and purpose: MS is one of the most common chronic diseases of the central nervous system. This disease causes many mental disorders in patients. The purpose of this study was to investigate the effectiveness of acceptance and commitment therapy on life expectancy and pain perception in patients with MS in Mashhad. Materials and methods: This was a semi-experimental study with a pre-test, post-test and control group design. The statistical population included all patients with MS in Hazrat Qaim (AS) hospital in Mashhad in 2022, from among whom 30 people were selected by available sampling method and randomly placed in two experimental and control groups, 15 people in each group. became The experimental group received 8 60-minute sessions of acceptance and commitment therapy, and the control group was placed on the waiting list. The research tool was Miller's Life Expectancy Questionnaire and McGill's Pain Perception Questionnaire. Research data were analyzed by multivariate covariance analysis and using SPSS version 21 software. Findings: The findings showed that acceptance and commitment therapy is effective on life expectancy and pain perception in patients with MS in Mashhad (P<0.05). Conclusion: Treatment based on acceptance and commitment can be a suitable treatment for improving the psychological factors of life expectancy and pain perception of patients with MS.
 

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