An Evaluation of the Effects of adding oral pregabaline to Morphine sulfate in Patients Receiving Intravenous PCA after orthopedic Surgery

imani, Farnad; Akhavan-akbari, Ghodrat; Mohammadian-erdi, Ali; Rahimzadeh, Puopak

Volume 2, Issue 2 (22 2011) JAP 2011, 2(2): 72-78 | Back to browse issues page

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imani F, Akhavan-akbari G, Mohammadian-erdi A, Rahimzadeh P. An Evaluation of the Effects of adding oral pregabaline to Morphine sulfate in Patients Receiving Intravenous PCA after orthopedic Surgery. JAP 2011; 2 (2) :72-78
URL: http://jap.iums.ac.ir/article-1-77-en.html

An Evaluation of the Effects of adding oral pregabaline to Morphine sulfate in Patients Receiving Intravenous PCA after orthopedic Surgery

Farnad Imani

, Ghodrat Akhavan-akbari

¹, Ali Mohammadian-erdi

, Puopak Rahimzadeh

Abstract: (6825 Views)

Background and aims: Although pregabalin shows efficacy against neuropathic pain, very limited evidence support postoperative analgesic efficacy. Our study objective to investigate analgesic efficacy of oral pregabalin in orthopedic surgery postoperative pain and opioid consumption.
Materials and methods: A randomized, double-blind, placebo-controlled was performed in . Patients received in first groupand in second group(30 patients) PCA morphine (10 mg/100ml) + oral pregabalin 300 mg daily for 48h after surgery. Pain score (VAS) and opioid consumption assessed in 48 hr after surgery.
Results: There was not significant difference between groups for demographic data. Pain score and opioid consumption in pregabaline group was significantly lower than morphine group without any significant complications.
Conclusions: preoperative oral dose of 300 mg pregabalindailyfor 48h after surgery reduces post operative acute pain in orthopedic surgery.