Journal of Anesthesiology and Pain

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 Aims and background: To enhance the quality of surgical procedures and to prevent surgical complications, anesthesia and analgesia techniques should be effective. Stress during surgery can disrupt the hemodynamic and physiological conditions of the human body. Different drugs are used to reduce the stress and each has advantages and disadvantages. The aim of this study was to investigate the effect of Esmolol infusion on the need for narcotic drugs during and after laparoscopic cholecystectomy. Materials and Methods: In this study, 60 patients who were candidate for laparoscopic cholecystectomy between 30 to 60 years old, were randomly selected and assigned to either Esmolol )E( or Saline )S(groups. Total opioid usage was recorded and compared during the operation. Findings: There was no statistically significant difference between the groups in mean intraoperative drug use )P= 0.9( and postoperative opioid use )P= 0.8(. Comparing the sedation score of the patients after the operation, there was no significant difference between the two groups (P= 0.4). conclusion: According to the findings of this study, Esmolol injection with 0.5 mg/kg dosage has no effect on the amount of opioid consumption during surgery and in the recovery; also it has no effect on sedation score of patients undergoing laparoscopic cholecystectomy.

Keywords: Esmolol- Opioids- Cholecystectomy

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