Journal of Anesthesiology and Pain

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 Aims and background: Post operative pain is the most common problem after surgeries. In the meanwhile, post operative pain in children is very important because tolerance to pain in children is lower; also use of opioid in children is limited. As using acetaminophen is increasing for pain relief, this study aimed to compare the effect of Acetaminophen with Morphine in decreasing post opearative pain in children undergoing laparoscopic apandectomy. Materials and Methods: In a clinical trial 80 children, candidate for apandectomy, were selected and randomly divided into two groups. The first group recevied 15 mg/kg acetaminophen in 100 ml normal saline and the second group received 0.01 mg/kg morphine intravenously and post operative pain and other complications such as nausea and vomitting and hemodynamic parameters during surgery and recovery were compared between the two groups. Data were analyzed by SPSS soft ware. Findings: According to Cheopsis score the mean post operative pain in the enterance to recovery in acetaminophen and morphine groups were 10.4±0.9 and 8.93±2, respectively and the difference between the two groups was statisticallysignificant (P<0.001). After 15 minutes in recovery the pain intensity in the two groups were 10.58±1.06 and 8.1±1.72, respectively and the difference was statisticallysignificant (P<0.001). The mean post operative painat the time of exit from recovery in acetaminophen and morphine groups were 10.28±1.2 and 8.03±1.8, respectively and the difference was again statistically significant (P<0.001). According to repeated measures ANOVA the trend of pain in the recovery was different between the two groups (P<0.001). conclusion: According to the results of the study, injection of acetaminophen before laparascopic apandectomy led to decreased post operative pain, decreased length of stay in recovery and decreased other post operative events such as nausea and vomitting. Therefore acetaminophen is a suitable replacement for control of post operative pain in children under laparoscopic apandectomy and this recommended except in the case of contraindication

Keywords: post operative pain, apandectomy, acetaminophen, morphine

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