Aim and Background: Chronic pain is a degenerative and disabling situation which is accompanied by several psychological variables. Therefore, this study aimed at investigating results the effectiveness of mindfulness-based stress reduction (MBSR) in reduction of catastrophizing, and pain intensity in patients suffering musculoskeletal chronic pain. Materials and methods: The present study was an sub - experimental study with pre-test and post-test design and a control group. The study statistical population included all the patients with musculoskeletal chronic pain referred to the professional clinic of pain of Tabriz in 2014 who overall, 40 patients were selected through purposive non-random sampling method based on pain specialist diagnosis, and clinical interview. Then participants were randomly allocated into two experimental and control groups. The instrumentals of this study were catastrophizing scale (PCS) and visual analog scale (VAS) who participants completed in pre-test and post-test. Descriptive statistical methods and covariance analysis were used for analysis of the data. Findings: The results showed that training mindfulness based stress was effective in reducing catastrophizing, and pain intensity in patients. Conclusion: Performing psychological treatments beside medicine treatment is effective in treating patients suffering chronic musculoskeletal pain
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