Aims and background:
Nowadays, multimodal approach is used to control post-operative pain.
Pregabalin has been shown to have analgesic effects on postoperative pain as a
Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind,
controlled study has evaluated the beneficial effect of Pregabalin pretreatment
on postoperative pain and opioid consumption in patints undergoing orthopedic
elective surgery.
Materials and Methods: Sixty ASA 1-2 patients,
scheduled for orthopedic elective surgery under spinal anesthesia, were
randomly divided into two groups. Group 1 received 300 mg Pregabalin one hour
before the operation and Group 2 was given Placebo capsule. Patient-controlled
intravenous analgesia (PCIA) device, prepared with Sufentanil, was connected to
both groups for postoperative analgesia. Postoperative pain scores according to
visual analogue scale (VAS), opioid consumption, and side-effects like nausea
were recorded for 12 hours after surgery. P value<0.05 was considered
significant.
Findings:
According to visual analogue scale (VAS), pain scores were significantly lower
in Pregabalin group at post anesthesia care unit (PACU), 6 hours and 12 hours
post-operatively(p<0.05). Also pethidine consumption was significantly less
than the placebo group in Pregabalin group (p<0.05).
Conclusion:
Administering a single dose of 300 mg Pregabalin orally, and 1 hour before
elective orthopedic surgery under spinal
anesthesia, significantly reduces postoperative pain and opioid consumption.
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