Journal of Anesthesiology and Pain

Abstract

Aim and Background:

This study is aimed to assess the effect of aminophylline (1mg/kg) on

reversal of the sedative effects of propofol and the recovery time in patients under propofol

anesthesia. Due to the known effects of aminophylline on myocardial contractility and the

increase in cardiac output, its effects on hemodynamic changes of propofol are also assessed.

Methods and Materials:

In a double blinded randomized clinical trial on 154 patients, intubation

was done after induction of anesthesia with sufentanil (0.2 mcg/kg), propofol (2.5 mg/kg) and

atracurium (0.5 mg/kg). Anesthesia was maintained with 200 mcg/kg/min of propofol infusion.

After discontinuing propofol at the end of the surgery patients were randomly allocated to receive

either aminophylline 1 mg/kg or normal. Heart rate, blood pressure and oxygen saturation were

recorded before and after injection, and every 2 minutes until extubation was performed, and

thereafter every 5 minutes till the patients’ discharge from recovery. The time interval between

injection and extubation plus the duration of recovery stay were also recorded.

Findings:

The mean arterial pressure 2,6, and 8 minutes post-extubation the heart rate 2,4,6, and

8 minutes just after extubation and oxygen saturation 2,4,5, and 10 minutes post-extubation

were higher in the aminophylline group. The discharge time was on the contrary, shorter in this

group.

Conclusions:

Aminophylline (1mg/kg) will result in a shorter recovery time following propofol