Journal of Anesthesiology and Pain

Background and aims
The objective of our study was so to show the efficacy of PCIA with morphine or lornoxicam on the attenuation of postoperative pain after laparoscopic gastric bypass surgery.
Methods
In this randomized clinical trial, 60 patients who were candidates for laparoscopic gastric bypass surgery were included. Patients were randomly receiving morphine (n=30) or lornoxicam (n=30) through PCIA for postoperative pain relief, at the end of the procedure. Visual analogue scale (VAS), sedation score, and nausea and vomiting score (N&V score) were used up to 24 hours after laparoscopy. A physician, who was not aware of the therapy undertaken, evaluated the patients.
Results
There were no statistically significant differences between two groups according to age, gender, and body mass index. Before intervention, the means of pain intensity (VAS) in the morphine and lornoxicam groups were 6.3±1.7 and 6.6±1.5, respectively. After 24 hours, the means reduced to 1.6±0.8 and 1.7±0.5, respectively (p<0.001). The changes of pain score were the same in two groups. During 24 hours follow-up, the means of sedation and N&V scores in patients receiving morphine were higher than the patients receiving lornoxicam significantly.
Conclusion
Our finding suggests that administration of lornoxicam through PCIA is as effective as administration of morphine through PCIA with in management of post-operative pain in patients undergone laparoscopic surgery. In addition, lornoxicam has less side-effect such as sedation, nausea and vomiting than morphine.