Volume 6, Number 3 (4-2016)                   JAP 2016, 6(3): 44-53 | Back to browse issues page


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Jarineshin H, Mehrabani S, Kargar A, Fekrat F. Spinal Anesthesia for cesarian section: A comparison between Hyperbaric and Isobaric Bupivacaine. JAP. 2016; 6 (3) :44-53
URL: http://jap.iums.ac.ir/article-1-5243-en.html

1- Assistant Professor of Anesthesiology, Cardiothoracic anesthesia fellowship Hormozgan University of Medical Sciences
2- Medical Student Hormozgan University of Medical Sciences
3- Resident of Anesthesiology Hormozgan University of Medical Sciences
4- Anesthesiologist Hormozgan University of Medical Sciences , fereydoonfekrat@yahoo.com
Abstract:   (1330 Views)

Aims and Background: The baricity of the solutions used for spinal anesthesia significantly affects the
distribution and dissemination of local anesthetics into the spinal space. The purpose of this study was to compare
the effects of hyperbaric and isobaric bupivacaine for spinal anesthesia in cesarean section.
Materials and Methods: This was a randomized double blind clinical trial on sixty patients (18-40 years
old) with ASA I-II, who were candidate for elective cesarean section. Spinal anesthesia was applied by isobaric
bupivacaine in the first group and hyperbaric bupivacaine in the second group. The data including hemodynamic
parameters of the patients, oxygen saturation level, sensory and motor block levels, and consumption of ephedrine
and complications of spinal anesthesia were all recorded. Statistical analysis by using SPSS software was applied
using T-test, Chi-square test, and repeated ANOVA. P values<0.05 were considered significant.
Findings: Patients in both groups were almost similar regarding demographic values and the duration of surgery.
Among the other recorded variables only the duration of analgesia and the frequency of nausea and vomiting was
considerably higherin the isobaric group compared with the hyperbaric one (P<0.001 , P= 0.001 respectively).
There was no significant difference between the two groups regarding the other variables.
Conclusions: Isobaric bupivacaine had the same effectiveness as hyperbaric type for spinal anesthesia, and it
even had a longer duration of analgesia. However the higher incidence of nausea and vomiting with isobaric type
must be taken into account.

Full-Text [PDF 382 kb]   (632 Downloads)    
Type of Study: Original | Subject: Regional anesthesia
Received: 2015.09.26 | Accepted: 2015.12.9 | Published: 2016.03.25

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