Volume 4, Number 1 (12-2013)                   JAP 2013, 4(1): 46-72 | Back to browse issues page


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Gousheh S M R, Tayaranian noorani H, pipelzadeh M R, Behaeen K, Olapure A. The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia. JAP. 2013; 4 (1) :46-72
URL: http://jap.iums.ac.ir/article-1-5058-en.html

1- Assistant professor of Anesthesiology Ahwaz University of medical science, Imam Khomeini Hospital
2- Anesthesilogist Mashhad University of medical science, Omolbanin Hospital , htn1385@yahoo.com
3- Associated professor of Anesthesiology Ahwaz University of medical science, Imam Khomeini Hospital
Abstract:   (2622 Views)

Aim and Background:

Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these response, so we examined the effects of maintaining a remifentanil infusion in the recovery room, on recovery profiles such as coughing and cardiovascular responses after general anesthesia.

Methods and Materials:

In a prospective, double-blinded, randomized trial, we enrolled 60 adult patients undergoing nasal surgery with remifentanil-based anesthesia. During the emergence phase, the infusion rate of remifentanil was reduced to 0.02 micro/kg/min in treatment group 1 and to 0.05 micro/kg/min in treatment group 2, whereas in the control group remifentail was discontinued and placebo was started instead.

Findings: 

During emergence, both of the treatment groups had a significantly lower incidence and severity of coughing and slower heart rate. The mean systolic blood pressure (MAP) in the treatment group 2 was significantly lower compared with the other groups, but the awakening or extubation time was prolonged in this group, whereas time interval to awakening and tracheal extubation was similar between the control group and treatment group 1.

Conclusions:

Maintaining a low-dose remifentanil infusion during emergence did not prolong awakening but reduced heart rate and the incidence and severity of coughing due to the endotracheal tube, whereas high-dose remifentanil infusion reduced the hemodynamic changes and coughing associated with tracheal extubation while significantly delaying the extubation time.

Full-Text [PDF 334 kb]   (939 Downloads)    
Type of Study: Original | Subject: Anesthesia Monitoring
Received: 2013.12.23 | Accepted: 2013.12.23 | Published: 2013.12.23

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