fa تأثیر تک دوز ایبوپروفن وریدی قبل از جراحی بر درد پس از بیهوشی: یک مرور سیستماتیک و متاآنالیز مانیتورینگ بیهوشی Anesthesia Monitoring مروری Review <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">مقدمه: در طی چند سال اخیر روند استفاده از داروهای غیراوپیوئیدی برای مدیریت درد پس از جراحی با استقبال بالایی همراه شده است و از طرفی با توجه به نتایج متناقض استفاده پیشگیرانه ایبوبروفین وریدی قبل از جراحی، مطالعه حاضر با هدف </span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">تأثیر تک دوز ایبوپروفن وریدی قبل از جراحی بر درد پس از بیهوشی به صورت مرور سیستماتیک و متاآنالیز انجام شد.</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">روش کار: این مطالعه به صورت مروری سیستماتیک و متاآنالیز در شش ماهه اول سال 1401 بر اساس بیانیه </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%">PRISMA</span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> انجام شد. بدین منظور </span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">کلیدواژه های ایبوپروفن، داخل وریدی، درد پس از جراحی، بی‌دردی، اوپیوئیدو بی‌دردی تحت کنترل بیمار در پایگاه های داده ای پابمد، اسکاپوس، </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">MEDLINE</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Embase</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، مرکز ثبت کارآزمایی‌های کنترل‌شده کاکرین و پایگاه‌های داده</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> Web of Science </span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، مگ ایران و </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">SID</span></span></span><span style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> جستجو شدند. </span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">نتایج:</span></span></span> <span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">بررسی شدت درد در ساعت 12 (64/1-=</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">MD</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">-( 56/2-،72/0-)95%</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">CI</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">- 001/0=</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> و 95%=</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">I²</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">) و 24 ساعت </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">(58/0-=</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">MD</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">-( 18/0-،99/0-)95%</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">CI</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">- 001/0=</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> و 90%=</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">I²</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">) </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">پس از اتمام جراحی حاکی از آن بود که تجویز پیشگیرانه ایبوبروفین به صورت چشمگیری منجر به کاهش شدت درد شده بود</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">.</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">نتیجه گیری: تجویز تک دوز پیشگیرانه ایبوبروفین وریدی منجر به کاهش شدت درد در طی 24 ساعت اول پس از جراحی می شود، با این حال اثرات آن با گذشت زمان کمتر می شود.</span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Introduction:</span></span></span></b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> During the last few years, the trend of using non-opioid drugs for the management of pain after surgery has been highly welcomed, and on the other hand, considering the contradictory results of the preventive use of intravenous ibuprofen before surgery, the present study aimed at the effect of a single dose of intravenous ibuprofen before surgery. A systematic review and meta-analysis was conducted on post-anesthesia pain surgery.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> This study was conducted as a systematic review and meta-analysis in the first six months of 1401 based on the PRISMA statement. For this purpose, the keywords of ibuprofen, intravenous, post-surgical pain, analgesia, opioid and analgesia under patient control in the databases PubMed, Scopus, MEDLINE, Embase, Cochrane Center for Controlled Trials and Web of Science, Mag Iran and SID databases.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> Examining pain intensity at 12 hours (MD=-1.64 (-2.56, -0.72), 95%CI P=0.001 and I=95%) and 24 hours (-0.58) MD = (-0.18, -0.99) 95% CI- P = 0.001 and I = 90%) after surgery indicated that prophylactic administration of ibuprofen significantly reduced pain intensity.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span lang="EN" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> The administration of a single prophylactic dose of intravenous ibuprofen leads to a decrease in pain intensity during the first 24 hours after surgery, however, its effects decrease over time.</span></span></span></span></span></span><br> &nbsp; ایبوبروفین, وریدی, تک دوز, درد, پیشگیرانه ibuprofen, intravenous, single dose, pain, preventive 152 161 http://jap.iums.ac.ir/browse.php?a_code=A-10-421-6&slc_lang=fa&sid=1 Mehdi Nazari مهدی نظری Bikaran_mmm@yahoo.com 100319475328460018507 100319475328460018507 No Pediatrice Assistant Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran استادیار بیهوشی، گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران Daryoush Sheikhzadeh داریوش شیخ زاده mkhanbabayi@yahoo.com 100319475328460018508 100319475328460018508 Yes Assistant Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran استادیار بیهوشی، گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران