fa مقایسه اثرات سداتیو رمیفنتانیل با پروپوفول در اعمال جراحی کاتاراکت سالمندان تحت بلوک موضعی رترو بولبار عمومى General پژوهشي Original <p class="MsoNormal" style="line-height: 150% margin: 0cm 0cm 10pt"><strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-language: FA mso-bidi-font-family: Nazanin">Background</span></strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-language: FA mso-bidi-font-family: Nazanin">:</span></p> <p class="MsoNormal" style="text-align: justify line-height: 150% margin: 0cm 0cm 10pt"><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-language: FA mso-bidi-font-family: Nazanin">Because general anesthesia is not a good choice in elderly ASA>II patients candidate for cataract surgery performored by ophthalmology Residents and lack of cooperation in these patients, </span><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin">sedative effect and hemodynamic status and side effects of two drugs, Remifentanil & propofol<span style="mso-spacerun: yes">  </span>are compared.</span></p> <p class="MsoNormal" style="text-align: justify margin: 0cm 0cm 0pt mso-layout-grid-align: none"><span style="line-height: 115% font-family: Nazanin color: black font-size: 16pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman""> </span></p> <p class="MsoNormal" style="line-height: 150% margin: 0cm 0cm 10pt"><strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-language: FA mso-bidi-font-family: Nazanin">Methods :</span></strong><strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin"> </span></strong></p> <p class="MsoNormal" style="text-align: justify margin: 0cm 0cm 10pt"><span style="line-height: 115% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin">In a Randomized clinical trial on 60 patients candidate for cataract surgery which were divided in two group each containing 30 patients were compared. In group A (remifentanil group), patients were sedated with a bolus dose of 0.5 µg/kg within 1 minute , and maintenance dose of 0.05 µg/kg/min. In group B ( propofol <span style="mso-spacerun: yes"> </span>group) , <span style="mso-spacerun: yes"> </span>patients were sedated with a bolus dose of 0.25 µg/kg, and maintenance dose of 25 µg/kg/min. After retrobulbar block was performored for all the patients by residents. Hemodynamic responses, including<span style="mso-spacerun: yes">  </span>HR , DBP , SBP<span style="mso-spacerun: yes">  </span>and O2Sat and sedation level according to MOAA/SS <span style="mso-spacerun: yes"> </span>were measured .</span></p> <p class="MsoNormal" style="text-align: justify line-height: 150% margin: 0cm -2.5pt 10pt 0cm unicode-bidi: embed direction: rtl" dir="rtl"><span style="font-family: Calibri"><span style="line-height: 150% color: black font-size: 14pt mso-bidi-font-family: Nazanin mso-bidi-language: FA" dir="ltr">Modified Observers Assessment of Awareness/Sedation Scale<span style="mso-spacerun: yes">   </span>= <span style="mso-spacerun: yes">  </span>MOAA/SS<span style="mso-spacerun: yes">            </span></span></span></p> <p class="MsoNormal" style="text-align: justify margin: 0cm 0cm 10pt"><span style="line-height: 115% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin"> </span></p> <p class="MsoNormal" style="line-height: 150% margin: 0cm 0cm 10pt"><strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-language: FA mso-bidi-font-family: Nazanin">Results:</span></strong><strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin"> </span></strong></p> <p class="MsoNormal" style="text-align: justify margin: 0cm 0cm 10pt"><span style="line-height: 115% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin"><span style="mso-spacerun: yes"> </span>Sedation was deeper in <span style="mso-spacerun: yes"> </span>group A <span style="mso-spacerun: yes"> </span>(Remifentanil ) measured in all times after Block and were statistically meaningful (p<0.05) .The heart rate was <span style="mso-spacerun: yes"> </span>reduced in<span style="mso-spacerun: yes">  </span>group A after 20 minutes after Block and were statistically meaningful ( p<0.05). 7 Cases <span style="mso-spacerun: yes"> </span>in group A ( Remifentanil ) had <span style="mso-spacerun: yes"> </span>nausea after drug administration <span style="mso-spacerun: yes"> </span>(P=0.011). </span></p> <p class="MsoNormal" style="line-height: 150% margin: 0cm 0cm 10pt"><strong><span style="line-height: 150% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-language: FA mso-bidi-font-family: Nazanin">Conclusion: </span></strong></p> <p class="MsoNormal" style="text-align: justify margin: 0cm 0cm 10pt"><span style="line-height: 115% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin"><span style="mso-spacerun: yes"> </span>Remifentanil can induce high level of sedation for patients compare to propofol. But Nausea could be troublesome and in this point propofol has less adverse effect. </span></p> <p class="MsoNormal" style="text-align: justify margin: 0cm 0cm 10pt"><span style="line-height: 115% font-family: "Times New Roman","serif" color: black font-size: 16pt mso-bidi-font-family: Nazanin"> </span></p> 81 0 http://jap.iums.ac.ir/browse.php?a_code=A-10-25-43&slc_lang=fa&sid=1 Mahzad Alimian, Farnad Imani, Mahmoudreza Alebouyeh Behrouz Zaman, Alirezqa Siamdoust, Reza Tarjoman مهزاد علیمیان 100319475328460090 100319475328460090 No فرناد ایمانی 100319475328460091 100319475328460091 No محمودرضا آل بویه 100319475328460092 100319475328460092 No بهروز زمان 100319475328460093 100319475328460093 No علیرضا صیام دوست 100319475328460094 100319475328460094 No رضا پرشکوه 100319475328460095 100319475328460095 No