fa تاثیر تک  دوز پره¬گابالین قبل از عمل بر میزان درد پس از اعمال کوچک جراحی عمومى General پژوهشي Original <p class="MsoNormal" style="text-align: justify margin: 0cm -34.7pt 0pt -14.2pt" dir="rtl"><strong><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma">زمینه و هدف:</span></strong><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma"> درمان درد حاد بعد از اعمال کوچک جراحی از اهمیت ویژه­ی برخوردار است. </span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">پره­گابالین درکنترل دردهای مزمن نورپاتیک موثر بوده، ولی مطالعات اندکی در مورد تاثیر آن در کنترل درد حاد بعد از عمل وجود دارد. هدف از این مطالعه بررسی تاثیر یک مقدار تنهای خوراکی پره­گابالین درکنترل درد و کاهش مصرف مخدر بعد از اعمال </span><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma">کوچک جراحی </span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">می­باشد.</span></p> <p class="MsoNormal" style="text-align: justify margin: 0cm -34.7pt 0pt -14.2pt" dir="rtl"><strong><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma">مواد و روش­ها:</span></strong><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma"> تعداد 60 بیمار کاندید اعمال کوچک جراحی تحت بیهوشی عمومی بصورت تصادفی انتخاب شده و به دو گروه تقسیم شدند: گروه مورد پره­گابالین 150 میلی­گرم و گروه شاهد دارونما یک ساعت قبل از عمل دریافت کردند. </span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">روش بیهوشی در هر دو گروه یکسان بود. پس از عمل در صورت نمره درد بالاتر از 3، پتیدین وریدی 25 میلی­گرم تزریق می­گردید. نمره درد بیماران با روش نمره بندی مشابه بینایی </span><span style="font-family: "Arial","sans-serif" color: black font-size: 14pt mso-bidi-font-family: "B Nazanin"">VAS</span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial"> و مقدار مصرف پتیدین</span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-bidi-language: FA mso-ascii-font-family: Arial mso-hansi-font-family: Arial"> و عوارض</span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial"> </span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">تا 24 ساعت بعد از عمل ثبت گردید. </span><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma">سطح معنی</span><span style="font-family: "Tahoma","sans-serif" font-size: 14pt mso-bidi-font-family: "B Nazanin"">­</span><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma">دار این مطالعه 05/0 در نظرگرفته شد.</span></p> <p class="MsoNormal" style="margin: 0cm -34.7pt 0pt -14.2pt background: white" dir="rtl"><strong><span style="font-family: "B Nazanin" font-size: 14pt">یافته­ها: </span></strong><span style="font-family: "B Nazanin" font-size: 14pt">مشخصات دموگرافیک در دو گروه تفاوت معنی­داری با هم نداشت.<strong> </strong><a name="OLE_LINK67"></a><a name="OLE_LINK68"><span style="mso-bookmark: OLE_LINK67">نمره درد و مصرف مخدر در 24 ساعت پس از عمل در</span></a></span><span style="mso-bookmark: OLE_LINK68"><span style="mso-bookmark: OLE_LINK67"><span style="font-family: "B Nazanin" font-size: 14pt mso-bidi-language: FA"> </span></span></span><span style="mso-bookmark: OLE_LINK68"><span style="mso-bookmark: OLE_LINK67"><span style="font-family: "B Nazanin" font-size: 14pt">گروه پره­گابالین بطور معنی­داری کمتر از گروه شاهد و بدون عوارض بیشتر بود</span></span></span><span style="font-size: 14pt mso-bidi-font-family: &aposB Nazanin&apos" dir="ltr" lang="AR-SA"><span style="font-family: Times New Roman"> </span></span><span style="font-family: "B Nazanin" font-size: 14pt mso-bidi-language: FA">(01/0</span><span style="font-family: Times New Roman"><em><span style="font-size: 14pt mso-bidi-font-family: &aposB Nazanin&apos mso-bidi-language: FA" dir="ltr">P</span></em><span style="font-size: 14pt mso-bidi-font-family: &aposB Nazanin&apos mso-bidi-language: FA" dir="ltr"><</span></span><span style="font-family: "B Nazanin" font-size: 14pt mso-bidi-language: FA">)</span></p> <p class="MsoNormal" style="margin: 0cm -34.7pt 0pt -14.2pt background: white" dir="rtl"><strong><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">نتیجه­گیری</span></strong><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">: مصرف یک مقدار تنها ( 150 <span style="mso-spacerun: yes"> </span>میلی­گرم) پره</span><span style="color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial"><span style="font-family: Times New Roman">­</span></span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">گابالین خوراکی قبل از </span><span style="font-family: "B Nazanin" font-size: 14pt mso-ascii-font-family: Tahoma mso-hansi-font-family: Tahoma">اعمال کوچک جراحی </span><span style="font-family: "B Nazanin" color: black font-size: 14pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">می­تواند نمره درد و مصرف مخدر را در 24 ساعت بعد از عمل کاهش دهد.<span style="mso-spacerun: yes">    </span></span></p> <p><span style="font-family: TimesNewRomanPS-BoldMT"><font face="TimesNewRomanPS-BoldMT"> <p align="left"> </p> </font></span> <p align="left"> </p> </p> <p align="left"> <p><strong><span style="font-family: TimesNewRomanPS-BoldMT"><strong><font face="TimesNewRomanPS-BoldMT"> <p align="left">Aim and Background:</p> </font></strong></span> <p align="left"> </p> <span style="font-family: Times New Roman">Optimal postoperative pain management is necessary after minor general</span></strong></p> </p> <p align="left"><span style="font-family: Times New Roman">surgery. Although pregabalin had been showed efficacy against neuropathic pain<strong>, </strong>very limited</span></p> <p align="left"><span style="font-family: Times New Roman">evidence support its postoperative analgesic efficacy. The aim of this study was to evaluate the</span></p> <p align="left"><span style="font-family: Times New Roman">analgesic efficacy of premedication with single oral dose of pregabalin for minor general surgery.</span></p> <p align="left"> </p> <p><span style="font-family: TimesNewRomanPS-BoldMT"><font face="TimesNewRomanPS-BoldMT"> <p align="left"> </p> </font></span> <p align="left"> </p> <span style="font-family: TimesNewRomanPS-BoldMT"><font face="TimesNewRomanPS-BoldMT"> <p align="left"> </p> </font></span> <p align="left"> </p> </p> <p align="left"> </p> <p align="left"> </p> <p align="left"> </p> <p><span style="font-family: TimesNewRomanPS-BoldMT"><font face="TimesNewRomanPS-BoldMT"> <p align="left"> </p> </font></span> <p align="left"> </p> <span style="font-family: TimesNewRomanPS-BoldMT"><font face="TimesNewRomanPS-BoldMT"> <p> </p> </font></span> <p> </p> </p> <p> <p><strong><span style="font-family: TimesNewRomanPS-BoldMT"><strong><font face="TimesNewRomanPS-BoldMT"> <p align="left">Methods and Materials:</p> </font></strong></span> <p align="left"> </p> <p align="left"><span style="font-family: Times New Roman">Sixty patients candidate for minor general surgery under general <p align="left">anesthesia were randomly allocated into the two groups In intervention group Pregabalin 150mg</p> <p align="left">, and in control group placebo was administered one hour before surgery. Anesthesia method was</p> <p align="left">similar in both groups. If pain score (Visual Analogue Scale, VAS) was more than three,</p> <p align="left">pethidine 25mg intravenous was administrated. VAS, opioid consumption, and side effects were</p> <p align="left">recorded for 24 hours after surgery.</p> </span></p> <strong><span style="font-family: TimesNewRomanPS-BoldMT"><strong><font face="TimesNewRomanPS-BoldMT"> <p align="left">Findings:</p> </font></strong></span> <p align="left"> </p> <p align="left"><span style="font-family: Times New Roman">Demographic data was not significantly different between two groups. VAS and <p align="left">opioid consumption during the 24 hours postoperative period in pregabalin group was</p> <font face="Times New Roman"> <p align="left">significantly less than the placebo group without any more side effects (</p> </font></span></p> <p align="left"> </p> <em><span style="font-family: Times New Roman">p</span></em> <p align="left"><span style="font-family: Times New Roman"><0.01).</span></p> <strong><span style="font-family: TimesNewRomanPS-BoldMT"><strong><font face="TimesNewRomanPS-BoldMT"> <p align="left">Conclusions:</p> </font></strong></span> <p align="left"> </p> <p align="left"><span style="font-family: Times New Roman font-size: small"> <p align="left"><font face="Times New Roman" size="3">Preoperative administration of single oral dose of pregabalin 150mg reduced post</font></p> </span></p> <strong><span style="font-family: TimesNewRomanPS-BoldMT"><strong><font face="TimesNewRomanPS-BoldMT"> <p> </p> </font></strong></span> <p> </p> <p> </p> </strong></strong></strong></strong></p> </p> 180 0 http://jap.iums.ac.ir/browse.php?a_code=A-10-25-38&slc_lang=fa&sid=1 Farnad Imani1, Mahmoud Nezafati2, Majid Heidarian2 Mohammad Molla‐Soltani3,Keivan Niknam3 فرناد ایمانی 100319475328460068 100319475328460068 No محمود نظافتی 100319475328460069 100319475328460069 No مجید حیدریان 100319475328460070 100319475328460070 No محمد ملاسلطانی 100319475328460071 100319475328460071 No کیوان نیکنام 100319475328460072 100319475328460072 No