Background & Aim: In any era of history, human beings have been afraid of a disease. Undoubtedly, cancer is one of the most worrisome diseases and cancer pain is one of the most painful pain. The purpose of this study was to compare the efficacy of cognitive-behavioral group therapy and mindfulness therapy on the reduction of physical disability and pain relief in cancer patients.
 Method: Methods: The present study is applied in terms of purpose and in terms of quasi-experimental method with pre-test, post-test and two-month follow-up and control group. The statistical population was all women with breast cancer referred to Tehran Cancer Research Center in 1397 who were selected by available sampling method consisting of 30 patients and randomly divided into two groups of intervention therapy (cognitive-behavioral and mindfulness), and The control group was placed. The research instrument was the Physical Disability Scale Questionnaire (Roland and Morris, 1984) to assess the physical condition and pain intensity. For data analysis, a mixed analysis of variance design with repeated measures was used.
Results: The results of the analysis showed that there is a significant difference between the performance of the three groups in the physical disability and pain severity, but the effect of these two methods on the two groups was similar in reducing physical inability.
 Conclusion: In this study, in addition to medical treatment, cognitive / behavioral group therapy and knowledge of the mind are effective methods to minimize physical disability and severity of pain in cancer patients.

Keywords: Cancer, Cognitive -Meeting, Mindfulness, Pain management

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