Aims and background:  A major surgery such as a laparotomy can induce severe pain in a patient. However administration of pain control medications can have dramatic effects on the hemodynamic status of the patient. Therefore, the aim of this study was to investigate intravenous infusion of magnesium sulfate for pain control and its’ effect on the hemodynamic status of the patient after laparotomy surgery. Materials and methods:    In    this    clinical    trial    ,    80    patients    undergoing    laparotomy    surgery    were    randomly    classified    into intervention and control groups based on exclusion and inclusion criteria. The intervention group received a bolus of magnesium sulfate 50 mg /kg half an hour before surgery, and then an infusion of 500 mg /hr. for 24 hours    after    surgery.    P    <0.05    was    considered    significant. Findings: No    significant    difference    was    seen    before    and    after    surgery    between    the    intervention    and    control    groups    regarding hemodynamic status or pain severity up to 6 hours after surgery. However by 6 hours after surgery, the severity of pain in the intervention group was lower than in the control group. This difference was statistically significant    (P    =    0.01).    Conclusion: Magnesium sulfate has little effect on the hemodynamics of the patients undergoing surgery, but also    was    not    effective    for    the    control    of    pain    in    the    first    hours    after    surgery    However        six    hours    after    surgery    a    pain control effect was noted.

Keywords: Pain, Laparotomy, Magnesium Sulfate

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