Backgrounds: Several studies have shown that operating room and anesthesia nurse should have adequate knowledge in the field of cardiopulmonary resuscitation (CPR). The purpose of this study was to evaluate the knowledge of operating room and anesthesia students regarding accurate performing of CPR.

Methods: This research was a cross sectional study which compromise all 97 senior students of the operating room and anesthesia at the second semester in Yazd medical science University for the 2012 – 2013 school year. A two-part questionnaire was used to measure the knowledge of students. The first section included questions about age, gender and field and the second part was about correctly performed of cardiopulmonary resuscitation. The data analysis was done throw descriptive (frequency table, the percentage index of mean, median and standard deviation) and Mann–Whitney test using SPSS-19 software.

Results: The students’ knowledge during to confront with a patient with cardiopulmonary arrest and basic life support was well, while it was intermediate regarding advanced one and post managing of  cardio pulmonary resuscitation  .

Conclusion: Generally speaking, the knowledge of the participants in encounter with CPR case is intermediate and diverse necessary courses have been suggested.