Aims and Background: Bleeding during rhinoplasty is a complication that decreases the surgeon’s vision and even
causes more side effects. Different methods have been proposed to reduce bleeding during otorhinolaryngology
surgeries. The aim of this study is to compare the effect of tranexamic acid (TXA) and Dexmedetomidine (DEX)
on the amount of bleeding in patients candidate for rhinoplasty.
Materials and methods: In this randomized double-blind clinical trial, 76 patients who were candidate for
elective rhinoplasty surgery entered the study. The first group received 10 mg/kg Tranexamic acid (TXA), and
the second group received 1 μg/kg Dexmedetomidine (DEX) intravenously within 15 minutes immediately after
induction. Bleeding volume, hemodynamic parameters and surgeon’s satisfaction were evaluated.
Findings: The amount of intra-operative bleeding was 145.2±22.1 ml in DEX group and 141.8±24.1 ml in TXA
group (p=0.46). The mean score of surgeon’s satisfaction was 1.65±0.53 in DEX group and 1.42±0.64 in TXA
group (p=0.089).
Conclusions: Totally the efficacy of DEX and TXA was equal. TXA reduces bleeding in major surgeries but for
rhinoplasty, in which bleeding volume is not so much perhaps using DEX is a better option.