Volume 4, Issue 2 (7-2013)                   JAP 2013, 4(2): 216-222 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rahimzadeh P, Imani F, Faiz S, Mohsenpour A, Nasiri A. The effect of premedication with oral memantine on pain control after orthopedic surgery. JAP 2013; 4 (2) :216-222
URL: http://jap.iums.ac.ir/article-1-5013-en.html
Abstract:   (8628 Views)
Aim and Background: Memantine is one of NMDA receptor antagonists with a rapid onset and limited side effects its inhibitory effects on neuropathic pain has mentioned while using before nerve injury. Few studies were done on evaluating oral memantine effects on acute post-orthopedic surgery pain. Methods and Materials: In a double blind clinical trial, 60 patients with ASAI, II and upper limb fracture in two groups were enrolled in this study. After signing informed consent by the patients, 1 hour before surgery 20mg memantine prescribed for case group and control group received placebo. The patients received fentanyl and midazolam as premedication then anesthesia induction with propofol and cisatracurium performned. Maintenance of anesthesia was propofol and remifentanil. Pain score with Visual Analogue Scale (VAS)and sedation score measured and recorded in recovery and 6,8,24,36 and48 hours later. Also total dose of opioid consumption and nausea and vomiting incidence was measured. Findings: No demographic differences exist between them. Pain score in recovery and 6, 24 hours later were lower in case group. Sedation score was significantly different in hour 24(P=0.04) Morphine dosage in case group was lower in recovery (P=0.01)Incidence of nausea and vomiting was not different between groups. Conclusions: Prescribing 20 mg memantine 1 hour before surgery, has been effective on pain reduction, also could decrease morphine demands in recovery.
Full-Text [PDF 261 kb]   (2319 Downloads)    
Type of Study: Original | Subject: Acute pain managment
Received: 2013.07.8 | Accepted: 2018.12.10 | Published: 2018.12.10

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Anesthesiology and Pain

Designed & Developed by : Yektaweb