@ARTICLE{Ghazi, author = {dargahi, roghaie and ghazi, ahmad and hashemi Pazikoueii, fatemeh and amani, firoz and }, title = { A comparative study about the efficacy of Entonox Gas analegesia alone and in combination with dexamethasone in painless labor}, volume = {8}, number = {4}, abstract ={Aim and background: Labor pain is often severe. Unrelieved labor pain can have adverse effects on the physiologic status of mother. Pain during labor is accompanied by fear, which is related to slower progress of labor. Accurate measurement and appropriate management of pain is of great concern for medical and nursing personnel. There are choices to be made during pregnancy about options available for pain relief during labor; each method has its own risks and benefits, with variable efficacy, availability and acceptability. The purpose of this study is the comparison of analgesic effect of inhaling Entonox with and without dexamethasone among women undergoing normal vaginal delivery in Alavi hospital in 1394-95. Materials and Methods: In this clinical trial study in Alavi hospital, 100 women with term pregnancy were observed. 10 people were excluded due to various reasons and finally the subjects were divided into two groups of A and B, randomly. Group A received inhaled Entonox and placebo (45 cases) and group B received inhaled Entonox and 8 mg intramuscular Dexamethasone (45 cases). VAS and NRS pain score was measured before intervention and 3 hours and 6 hours after intervention. Finally the the Data was analyzed by SPSS. Findings: Pain severity according to VAS and NRS score was significantly lower in patient in group B who received nitrous oxide and dexamethasone 3 hours after the intervention (P=0.0001). There was not a significant difference in the duration of labor, number of uterine contractions and infant complications. Analysis of the maternal vital signs between the two groups showed that none of investigated vital signs was significantly different between the two groups except SBP. Significant difference was observed among the groups regarding Apgar scores in 1st and 5th minutes. Analysis of the pooled risk differences showed that none of the side effects investigated was significantly different between two groups except nausea and vomiting which was significantly higher in nitrous oxide users. conclusion: Use of nitrous oxide and dexamethasone has more beneficial effects for many parturient women. }, URL = {http://jap.iums.ac.ir/article-1-5341-en.html}, eprint = {http://jap.iums.ac.ir/article-1-5341-en.pdf}, journal = {Anesthesiology and Pain}, doi = {}, year = {2018} }