TY - JOUR JF - jap JO - JAP VL - 1 IS - 4 PY - 2011 Y1 - 2011/1/01 TI - Effect of adding magnesium to bupivacaine and fentanyl for spinal anesthesia in lower limb orthopaedic surgeries TT - بررسی اثر افزودن منیزیوم سولفات به بوپی واکائین و فنتانیل در بی حسی نخاعی در بیماران تحت اعمال جراحی ارتوپدی اندام تحتانی N2 - Background and aim: In recent years spinal anesthesia using a local anesthetic incombination with an opioid has gained popularity for lower limb operations due to the highsuccess rate and patient satisfaction, and the decreased resource utilization compared withgeneral anesthesia. In experimental studies, intrathecal administration of magnesium sulphate(MgSO4) significantly potentiated antinociception during spinal anesthesia however availabledata are scarce. This study aimed at evaluating the effect of adding MgSO4 to bupivacaine andfentanyl for spinal anesthesia in lower limb orthopaedic surgeries.Methods & materials: In this double-blind randomized clinical trial, 100 candidates ofspinal anesthesia for lower limp orthopaedic surgeries (ASA class I-II) were recruited in HazratRasoul Akram Medical Complrx in a 10-month period. They randomized in two equal age- andsex-matched groups receiving 1.0 ml of preservative-free 0.9% sodium chloride (group S) or 50mg of MgSO4 5% (1.0 ml) (group M) following 12.5 mg of bupivacaine 0.5% plus 25 μg offentanyl intrathecally. Date were collected regarding the time to reach the highest level ofsensory blockade, time to L2 regression, times to reach the highest level of motor blockade andits full regression, time to consumption the first dose of postoperative analgesic andcomplications.Results: Median time to reach the highest level of sensory blockade was significantly higherin the S group (16 vs. 14.5 min p=0.02). Median time to L2 regression (243 vs. 207 minp SP - 43 EP - 51 AU - Alebouyeh, Mahmoud-reza AU - Iman, Farnad AU - Entazary, Saeid-reza AU - Yusefvand-Mansuri, Tiam AU - Rahimzaheh, Poupak AD - KW - Analgesic KW - bupivacaine KW - fentanyl KW - magnesium sulphate KW - spinal anesthesia KW - lower limb surgery UR - http://jap.iums.ac.ir/article-1-93-en.html ER -