TY - JOUR JF - jap JO - JAP VL - 1 IS - 3 PY - 2010 Y1 - 2010/10/01 TI - Evaluation the Efficacy of Intrathecal injection of Amitryptiline and Doxepin in Spinal Anesthesia and in comparison with Bupivacaine in Rats TT - بررسی تاًثیرتزریق اینتراتکال آمی تریپتیلین ودوکسپین در ایجاد بیحسی نخاعی و مقایسه آن با بوپیواکائین N2 - Background and aimsNowadays tricyclic antidepressants (TCAs) are commonly used orally for treating chronic pain states, such as neuropathic pain. TCAs produce analgesia by various mechanisms involving Sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenuates pain and thermal hyperalgesia in inflammatory and neuropathic pain in rats.Materials and methodIn a double blind RCT study in animal lab intathecal injection of drugs performed in 30 Wistar male rats .They devided in 3 groupes. In G1, 90 μl Doxepine (50 mM), G2, 90 μl amitriptyline (60mM) and in G3, 90 μl bupivacaine(23 mM) was injected. Then sensory, motor and proprioceptive changes was measured in these hours: 1, 2, 3, 4, 6 and 12 by one examinerResultsThree rats died in G1 and G2. After adjusting the influences from different concentrations, amitriptyline had a similar potency but a longer duration of spinal blockade of motor, propioception, and nociception than did bupivacaine(p value SP - 45 EP - 52 AU - Alebouyeh, Mahmoud-reza AU - Iman, Farnad AU - Rahimzadeh, Poupak AU - Mohammadian-erdi, Ali AU - Faiz, Seyyed Hamid-reza AD - KW - Doxepine KW - amitriptyline KW - bupivacaine KW - spinal blockade UR - http://jap.iums.ac.ir/article-1-101-en.html ER -