TY - JOUR T1 - post oprative pain managment TT - استفاده از گاباپنتینوئیدها بعنوان داروی کمکی در درمان درد پس از عمل جراحی JF - jap JO - jap VL - 5 IS - 1 UR - http://jap.iums.ac.ir/article-1-5097-en.html Y1 - 2014 SP - 1 EP - 2 N2 -   References: 1. Miller RD. Miller’s anesthesia. 7th ed. Philadelphia: Churchill Livingstone 2010 2758-9. 2. Macintyre PE, Schug SA, Scott DA, Visser EJ, Walker SM. APM:SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine. Acute Pain Management: Scientific Evidence. 3rd ed. Melbourne: ANZCA & FPM 2010 9-12. 3. Buvanendran A. Chronic Postsurgical Pain: Are We Closer to Understanding the Puzzle? Anesth Analg 2012115(2):231-2 4. Ramaswamy S, Wilson JA, Colvin L. Non-opioid-based adjuvant analgesia in perioperative care. BJA: CEACCP 201313(5):152-7 5. Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis. Anesth Analg 2012 115(2):428-442. 6. Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do Surgical Patients Benefit from Perioperative Gabapentin/Pregabalin? A Systematic Review of Efficacy and Safety. Anesth Analg 2007 104(6):1545–56 . 7. Schmidt PC, Ruchelli G, Mackey SC, Carroll IR. Perioperative Gabapentinoids: Choice of Agent, Dose, Timing, and Effects on Chronic Postsurgical Pain. Anesthesiology 2013 119(5):1215-21 . 8. Bauer CS, Rahman W, Tran-Van-Minh A, Lujan R, Dickenson AH, Dolphin AC. The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminals in vivo. Biochem. Soc. Trans 2010 38(2):525–528 . 9. Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr. Opin. Pharmacol 20066(1):108–113 . 10. Weinbroum AA. Non-opioid IV adjuvants in the perioperative period: Pharmacological and clinical aspects of ketamine and gabapentinoids. Pharmacol. Res 2012 65(4):411-29.             M3 ER -