TY - JOUR T1 - The effect of premedication with 300 mg Pregabalin on postoperative pain and opioid consumption in patients undergoing elective orthopedic surgery TT - اثر پیش درمانی با 300 میلی گرم پره گابالین خوراکی بر درد و مصرف مخدر پس از عمل در بیماران تحت اعمال جراحی الکتیو ارتوپدی JF - jap JO - jap VL - 5 IS - 3 UR - http://jap.iums.ac.ir/article-1-5162-en.html Y1 - 2014 SP - 29 EP - 35 KW - Orthopedic surgery KW - spinal anesthesia KW - Pregabalin KW - post-operative pain N2 - Aims and background:  Nowadays, multimodal approach is used to control post-operative pain. Pregabalin has been shown to have analgesic effects on postoperative pain as a Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind, controlled study has evaluated the beneficial effect of Pregabalin pretreatment on postoperative pain and opioid consumption in patints undergoing orthopedic elective surgery. Materials and Methods: Sixty ASA 1-2 patients, scheduled for orthopedic elective surgery under spinal anesthesia, were randomly divided into two groups. Group 1 received 300 mg Pregabalin one hour before the operation and Group 2 was given Placebo capsule. Patient-controlled intravenous analgesia (PCIA) device, prepared with Sufentanil, was connected to both groups for postoperative analgesia. Postoperative pain scores according to visual analogue scale (VAS), opioid consumption, and side-effects like nausea were recorded for 12 hours after surgery. P value M3 ER -