%0 Journal Article %A Naderi nabi, Bahram %A Haghighi, Mohammad %A Sedighinejad, Abbas %A Palizkar, Maryam %A Fathi, Amirhossein %A Pourreza, Maryam %A Behzadnia, Hamid %T The effect of premedication with 300 mg Pregabalin on postoperative pain and opioid consumption in patients undergoing elective orthopedic surgery %J Anesthesiology and Pain %V 5 %N 3 %U http://jap.iums.ac.ir/article-1-5162-en.html %R %D 2014 %K Orthopedic surgery, spinal anesthesia, Pregabalin, post-operative pain, %X Aims and background:  Nowadays, multimodal approach is used to control post-operative pain. Pregabalin has been shown to have analgesic effects on postoperative pain as a Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind, controlled study has evaluated the beneficial effect of Pregabalin pretreatment on postoperative pain and opioid consumption in patints undergoing orthopedic elective surgery. Materials and Methods: Sixty ASA 1-2 patients, scheduled for orthopedic elective surgery under spinal anesthesia, were randomly divided into two groups. Group 1 received 300 mg Pregabalin one hour before the operation and Group 2 was given Placebo capsule. Patient-controlled intravenous analgesia (PCIA) device, prepared with Sufentanil, was connected to both groups for postoperative analgesia. Postoperative pain scores according to visual analogue scale (VAS), opioid consumption, and side-effects like nausea were recorded for 12 hours after surgery. P value %> http://jap.iums.ac.ir/article-1-5162-en.pdf %P 29-35 %& 29 %! %9 Original %L A-10-163-6 %+ %G eng %@ 2228-6659 %[ 2014