@ARTICLE{Haghighi, author = {Naderi nabi, Bahram and Haghighi, Mohammad and Sedighinejad, Abbas and Palizkar, Maryam and Fathi, Amirhossein and Pourreza, Maryam and Behzadnia, Hamid and }, title = { The effect of premedication with 300 mg Pregabalin on postoperative pain and opioid consumption in patients undergoing elective orthopedic surgery}, volume = {5}, number = {3}, abstract ={Aims and background:  Nowadays, multimodal approach is used to control post-operative pain. Pregabalin has been shown to have analgesic effects on postoperative pain as a Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind, controlled study has evaluated the beneficial effect of Pregabalin pretreatment on postoperative pain and opioid consumption in patints undergoing orthopedic elective surgery. Materials and Methods: Sixty ASA 1-2 patients, scheduled for orthopedic elective surgery under spinal anesthesia, were randomly divided into two groups. Group 1 received 300 mg Pregabalin one hour before the operation and Group 2 was given Placebo capsule. Patient-controlled intravenous analgesia (PCIA) device, prepared with Sufentanil, was connected to both groups for postoperative analgesia. Postoperative pain scores according to visual analogue scale (VAS), opioid consumption, and side-effects like nausea were recorded for 12 hours after surgery. P value }, URL = {http://jap.iums.ac.ir/article-1-5162-en.html}, eprint = {http://jap.iums.ac.ir/article-1-5162-en.pdf}, journal = {Anesthesiology and Pain}, doi = {}, year = {2014} }