TY - JOUR T1 - Evaluating the effect of adding Magnesium sulfate to intrathecal lidocaine on duration of postoperative analgesia in lower limb orthopedic surgeries TT - بررسی تاثیر اضافه کردن سولفات منیزیوم به لیدوکائین اینتراتکال بر مدت بی دردی پس از اعمال ارتوپدی اندام تحتانی JF - jap JO - jap VL - 5 IS - 3 UR - http://jap.iums.ac.ir/article-1-5161-en.html Y1 - 2014 SP - 20 EP - 28 KW - Magnesium sulfate KW - lidocaine KW - postoperative pain N2 - Aims and background: Due to the nature of the orthopaedic surgery, affecting bone and joint, it is associated with a high rate of postoperative pain. Using intravenous, intramuscular, intrathecal and epidural opioids are methods for postoperative pain control for which the side effects are numerous. However, Intrathecal administration of magnesium with blocking NMDA receptors reduces postoperative pain without increasing side effects .The aim of this study was to investigate the effect of adding magnesium sulfate to Intrathecal lidocaine- epinephrine mixture on duration of postoperative analgesia in lower limb orthopaedic surgeries. Materials and Methods: This double blind study was performed on patients who were candidate for lower extremity orthopaedic surgeries. For this purpose, 156 patients were randomly divided into two groups. One group received magnesium sulfate with lidocaine – epinephrine mixture and other group received the same drugs with distilled water as placebo. The duration of postoperative pain was determined according to patients' request for analgesics. Patients' pain degree was evaluated according to visual analogue score (VAS), and Pethedine consumption was also calculated. Data were analyzed by SPSS software. Findings: Mean age of our patients in magnesium and control groups were 34.5 ±7.5 and 31.9±8.1 years old, respectively. The Mean (±SD) of postoperative analgesia duration in the magnesium group was 143.7±29.7min and it was 100.9±18.1 min in the control group, which shows a significant difference between two groups (p M3 ER -