Volume 2, Number 6 (18 2012)                   JAP 2012, 2(6): 30-37 | Back to browse issues page


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Hassani V, imani F, Alimian M, abdolalizadeh M. Comparing the analgesic effect Pregabalin and Gabapentin as premedication in laparoscopic procedures. JAP. 2012; 2 (6) :30-37
URL: http://jap.iums.ac.ir/article-1-55-en.html

Abstract:   (4718 Views)

Background: Laparascopic surgery is associated with post operative pain .optimal pain treatment with minimal side effects is essential for early recovery and mobility in patients undergoing laparoscopic surgery .we compaired the analgesic effect Pregabalin and Gabapentin with different doses in this surgical procedurs.
Methods: In a randomized , double blind , ninety patients were  allocated to either Group A Pregabalin 300mg , GroupB Gabapentin 600mg and GroupC Gabapentin 900mg .these were administered 1 h before operation .General anesthesia was performed .we collected data on pain intensity through Visual Analogue Scale (VAS) in recovery , 6 , 24 h after operation. Consumption of supp Diclofenac were recorded . p<0.05  was considered statistically significant.
Results:  Pregabalin 300 mg  was significantly more effective in reducing post operative pain up to 24 hours following  the surgery (p<0.001) . Furthermore , the amount of analgesic consumption was less in the  Pregabalin group (p<0.001). consumption analgesic and VAS were more than the other groups in patient who receive Gabapentin 600 mg.
Conclusions: Our finding showed that single dose of  pregabalin 300mg oral  is more effective than Gabapatin on the management of postoperative pain following abdominal laparoscopic surgery. And Pregabalin resulted in reduction in 24 h postoperative analgesic requirements.Gabapentin 900mg decrease VAS and consumption of analgesic significantly.

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Type of Study: Original | Subject: General
Received: 2011.12.10 | Accepted: 2011.12.31 | Published: 2013.06.10

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