Volume 7, Issue 1 (10-2016)                   JAP 2016, 7(1): 11-20 | Back to browse issues page


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Comparison of changes in serum interleukin, in patients with morbid obesity under laparoscopic gastric bypass surgery, before and after general anesthesia with isoflurane and propofol. JAP. 2016; 7 (1) :11-20
URL: http://jap.iums.ac.ir/article-1-5296-en.html

Abstract:   (1271 Views)

Introduction: Anesthesia can change the balance between proinflammatory and                anti-inflammatory cytokine factors during surgery. As a result of interference in the balance of these factors, increase the risk of cardiac and pulmonary disorders, blood glucose levels with insulin resistance, impaired function and damage to the patient's anesthesia. The aim of this study was to investigate the pattern of IL-10 and TNF-α with two type of anesthesia in surgery of Roux-en-Y laparoscopic gastric.

Material: 64 patients undergoing laparoscopic gastric bypass referring to Hazrat Rasoul Hospital as a random and using block randomization and parallel divided into two groups. After pre-oxygenation, anesthesia induction and patient intubation, as the maintenance of anesthesia during the operation, in first group isoflurane 1.2% is used and in second group propofol 100 μ / kg/ min is used intravenously. Then in groups, interluekin 10 and TNFα by ELISA method is measured.

Result: According to the results, the amount of IL-10 in both types of anesthesia increased, but increasing the amount of IL-10 in the propofol group showed unprecedented high. The amount of TNF-alpha in the isoflurane group; a little high, but decreased in the propofol group. The results of the statistical confidence level p <0.05 was significant.

Conclusion: Intraoperative stress factors responsible for the increase inflammation factor such as TNF-α. The use of drugs, such as propofol, may be helpful for reduce inflammation during surgery.

Full-Text [PDF 362 kb]   (451 Downloads)    
Type of Study: Original | Subject: Regional anesthesia
Received: 2016.06.11 | Accepted: 2016.09.14 | Published: 2016.12.16

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