Volume 7, Issue 2 (1-2017)                   JAP 2017, 7(2): 72-78 | Back to browse issues page


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Keramati K, jebelli javan A, abdollahi M, asghari bagh kheirati A. The experimental study on effect the extract of Commiphora mukul on visceral pain in mice. JAP. 2017; 7 (2) :72-78
URL: http://jap.iums.ac.ir/article-1-5295-en.html

1- assistant of professor semnan uni
2- associated of professor semnan uni
3- student semnan uni , Mostafadvm.abdollahi@gmail.com
4- student semnan uni
Abstract:   (1647 Views)

Aims and Background: Visceral pain is  unpleasant felling that there are same serious side effects associated with using synthetic drugs for its treatment, such as psychological dependence, gastric ulcers and blood dyscrasia and for decreasing these side effects, administration of herbal medicine can be appropriate approach. The aim of this study was to evaluate the palliative effect of Commiphora  mukul hydroalcholic extract on visceral pain.

Methods: This experimental study was done on 40 NMRI male mice. (36±4g). Mice were divided randomly into negative control group, positive control group (Ketoprofen), treatment 1 , treatment 2 ,treatment 3. Respectively Control group and positive group received normal salin and Ketoprofen (25mg/kg) and also treatment groups respectively received 100, 200 ,300 mg/kg of Commiphora mukul intraperitoneally. 15minute after each injection , for visceral pain induction, mices were injected by acetic acid 0.6% (10mg/kg) and during  30 minutes, the analgesic effect was recorded by counting the number of Writing. Datas were analyzed by SPSS statistical software , One-Way ANOVA and Tukey test with the significant level of P< 0.05.

Results: Hydroalcoholic extracts of Commiphora mukul  at 100, 200 and 300 mg/kg induced a significant reduction in pain response when compared to negative control group (p<0.05) ,also there was not any significant difference between treatments groups and positive control group(p>0.05).

Conclusion: This study confirmed the palliative properties of Commiphora mukul on visceral pain but further clinical studies are necessary to find out a suitable place for it among the other visceral analgesics.

Full-Text [PDF 299 kb]   (426 Downloads)    
Type of Study: Original | Subject: Chronic pain managment
Received: 2016.06.5 | Accepted: 2016.12.24 | Published: 2016.12.30

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