Volume 1, Issue 4 (22 2011)                   JAP 2011, 1(4): 41-47 | Back to browse issues page

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Imani F, Radmehr M, Mohammadian-erdi A, Entezary S, Alimian M. Evaluation of adding Acetaminophen to Fentanyl in Patient-Controlled IV Analgesia (PCIA) after Lower Limb Orthopedic Surgery. JAP. 2011; 1 (4) :41-47
URL: http://jap.iums.ac.ir/article-1-5144-en.html
1- Associate Professor of Anesthesiology Department of Anesthesiology and Pain Medicine, Rasoul-Akram Medical Center, Tehran University of Medical Sciences
2- Pain Fellowship, Assistant Professor of Anesthesiology Jahrom University of Medical Sciences , m_radmehri@yahoo.com
3- Pain Fellowship, Assistant Professor of Anesthesiology Ardabil University of Medical Sciences
4- Assistant Professor of Anesthesiology Department of Anesthesiology, Rasoul-Akram Medical Center, Tehran University of Medical Sciences.
Abstract:   (3814 Views)

Background and aims:

 Postoperative analgesia is one of the most concerns of anesthesiologist and patients. Systemic opioids administration is the gold standard in reducing the severe pain after surgery but some side effects prevent the use of adequate doses of opioids. The aim of this study was evaluation of adding acetaminophen on fentanyl in patient-controlled iv analgesia (PCIA).
Materials and Methods:

 In this randomized clinical trial, 120 patients candidate for lower limb orthopedic surgery (ASA I-II) were recruited in Rasoul-Akram Medical Center in a 12- month period. They randomly allocated  in two groups for postoperative pain, group F (Fentanyl)  (n=60)  and group AF (Acetaminophen/ Fentanyl) (n=60) by patient-controledl  intravenous analgesia (PCIA) groups. The pump has a continuous infusion of 5 ml per hour, bolus dose 2 ml and the lock out time 30 minutes was left. Each ml of solution in group F containing 10 mcg of fentanyl and in the group AF containing 5 mcg fentanyl and 20 mg acetaminophen. Pain score, sedation score, satisfaction, nausea and vomiting was evaluated for 48 hours after surgery.

The demographic characteristics of the two groups did not differ significantly. Pain scores beforpump  in F and AF groups were  6.8±1.6 and6.5±1.4, respectively. After 24 and 48 hours pain scores (2.4± 0.8, 1.7± 0.7) and (1.9± 0.6, 1.2± 0.5) decreased (P<0.001). Changes in pain scores were similar in both groups. Level of sedation, nausea and vomiting in the F group  and satisfaction in the AF group was higher. 

 This study showed adding iv acetaminophen to fentanyl through an PCIA is effective in controlling pain in patients undergoing lower limb orthopedic surgery. Moreover, acetaminophen and fentanyl combination and has fewer side effects such as nausea, vomiting and sedation and more satisfaction than fentanyl alone.

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Type of Study: Original | Subject: General
Received: 2014.07.9 | Accepted: 2014.07.9 | Published: 2014.07.9

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