Volume 4, Number 4 (Summer 2014)                   JAP 2014, 4(4): 19-31 | Back to browse issues page


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Hemmati K, Sayadizadeh T, Delpisheh A, Ahmadian Mazhyn Z. The effect of adding epinephrine to 5% lidocaine in spinal anesthesia for cesarean section in patients admitted to Mostafa Khomeini hospital in Ilam. JAP. 2014; 4 (4) :19-31
URL: http://jap.iums.ac.ir/article-1-5128-en.html

1- Assistant Professor of Anesthesiology Ilam University of medical sciences , khematy@gmail.com
2- Medical Student Ilam University of medical sciences
3- Associate Professor of Epidemiology Ilam University of medical sciences
Abstract:   (2650 Views)

 Aims and Background : One of the most common surgeries in women is cesarean section. Hence, it is important to choose an anesthetic technique which is safe, appropriate and affordable for mom and baby. Spinal anesthesia is one of such techniques for which drugs with the least possible damage and most efficacy should be chosen. Among the additives to local anesthetics, "epinephrine" is an appropriate choice. Epinephrine is commonly used together with local anesthetic to induce tense block and it seems that adding epinephrine to lidocaine would improve sensory block during spinal anesthesia.

 Materials and Methods: This study is a randomized double blind clinical trial. 60 female patients were referred to the operating room of Mostafa Khomeini hospital in Ilam. The patients were divided into two groups receiving lidocaine alone and lidocaine plus epinephrine. The first group received 60mg lidocaine 5% and the second group received 60mg of lidocaine 5% and 0.2 mg epinephrine. Afterward, variables such as systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, and arterial oxygen saturation by pulse oximetry, level of sensory, motor and sympathetic block, and Apgar score of neonate at 1 and 5 minutes plus possible complications of anesthetic drugs were recorded. Finally the findings were analyzed by multivariate statistical methods.

 Findings: We measured different kinds of variables and the results are as follows. Average Pulse Rate after 5 minutes in the first and second groups were, 101/8 ± 31/51 and 107/4 ± 25/04, respectively. This was statistically significant among the groups. A higher level block was more common (with exception in one dermatome) in group one (lidocaine alone) which was confirmed to be statistically different (P <0/04). Regarding blood pressure decrease, no significant difference was shown between the two groups.

Conclusion: According to this study, we can conclude that there has been a longer continuation of the sensory, motor and sympathetic block in the group receiving lidocaine plus epinephrine in comparison with the group who received lidocaine alone. In this study the use of additional anesthetic agents was also dramatically reduced. This in fact expresses the efficacy of epinephrine in prolonging local anesthetic effect.

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Type of Study: Original | Subject: Regional anesthesia
Received: 2014.06.23 | Accepted: 2014.06.23 | Published: 2014.06.23

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