Volume 4, Number 3 (spring 2015)                   JAP 2015, 4(3): 45-53 | Back to browse issues page


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Kholdebarin A, Jalili S, Godrati M, Rahimzadeh P, Rokhtabnak F, Sayarifard A et al . The effect of oral clonidine on hemodynamics and postoperative pain in laparoscopic cholecystectomy. JAP. 2015; 4 (3) :45-53
URL: http://jap.iums.ac.ir/article-1-5118-en.html

1- Assistant Professor of Anesthesiology Firouzgar Hospital, Iran University of Medical Sciences
2- Resident of Anesthesiology Iran University of Medical Sciences
3- Assistant Professor of Anesthesiology Firouzgar Hospital, Iran University of Medical Sciences , mrghodrati@yahoo.com
4- Assistant Professor of Anesthesiology Rasoul-e- Akram Hospital, Iran University of Medical Sciences
5- Assistant Professor of Community Medicine Tehran University of Medical Sciences
6- Professor of Anesthesiology Shahid Beheshti University of Medical Sciences
Abstract:   (2705 Views)

 Aims and Background: Hemodynamic changes during laparoscopy and postoperative pain after laparoscopic surgery are important issues. Therefore, in this study we examined the effect of oral clonidine on hemodynamics and postoperative pain control after laparoscopic cholecystectomy.

Materials and Methods: The study was a randomized clinical trial. 61 patients, candidate for laparoscopic cholecystectomy, were randomly assigned into two groups. The intervention group received 0.2 mg oral clonidine one hour before anesthesia, and the control group was given placebo instead. The hemodynamic changes and postoperative pain were compared between the two groups.

Findings: Variations of Mean Arterial blood Pressure (P= 0.18) and heart rate (P= 0.15) in the two groups were not statistically significant during surgery. Postoperative analgesic intake in the first 60 minutes of recovery (P=0.006), and 24 hours after surgery (P=0.005) were both significantly lower in the clonidine group.

Conclusion: Although oral clonidine had no significant effect on hemodynamic changes during laparoscopic cholecystectomy but it caused a significant reduction in postoperative pain and analgesic requirement.
Full-Text [PDF 352 kb]   (675 Downloads)    
Type of Study: Original | Subject: Acute pain managment
Received: 2014.06.11 | Accepted: 2014.06.11 | Published: 2014.06.11

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