Volume 4, Number 3 (spring 2015)                   JAP 2015, 4(3): 3-8 | Back to browse issues page


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Alimian M, Mohseni M, Safaeian R, Majedi M A. Comparing the effect of Hydroxy ethyl starch with crystalloids on hemodynamic changes following spinal anesthesia in caesarean section. JAP. 2015; 4 (3) :3-8
URL: http://jap.iums.ac.ir/article-1-5095-en.html

1- Assistant professor of anesthesiology Iran University of Medical Sciences
2- Assistant professor of anesthesiology Iran University of Medical Sciences , Masood.mohsemi@gmail.com
3- Anesthesiologist
Abstract:   (11615 Views)

Aims and Background: Although controversial, many studies have shown effectiveness of colloid loading as a substitute for crystalloids on reducing the incidence of hypotension in spinal anesthesia. This study was conducted to compare the effects of three intravenous fluid regimens on hemodynamic changes following spinal anesthesia in cesarean section. The regimens included 6% Hydroxy ethyl starch 130/0.4 (HES) as a colloid and two crystalloids (lactated ringer’s solution and sodium chloride 0.9%).

 Methods and Materials: In a double-blind clinical trial, 90 otherwise healthy parturients candidate for elective caesarean section, were randomly allocated to receive lactated ringer’s solution (1000 ml), sodium chloride 0.9% (1000 ml) or HES (7.5 mL/Kg) as preloading before spinal anesthesia. Hemodynamic parameters including blood pressure and heart rate, umbilical cord blood pH and the neonatal Apgar score were compared among the three groups.

 Findings: There was no difference in the basic hemodynamic measurements among the three groups. The incidence of hypotension and the required dose of ephedrine were lower in HES group (p=0.008). There was no significant difference in umbilical cord blood PH or Apgar scores among the intervention groups.

  Conclusion: Preloading with HES is more effective than crystalloids in preventing hypotension after spinal anesthesia without leading to a significant difference in Apgar score and umblical cord blood pH.

Full-Text [PDF 261 kb]   (677 Downloads)    
Type of Study: Original | Subject: Anesthesia Monitoring
Received: 2014.03.5 | Accepted: 2014.03.5 | Published: 2014.03.5

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